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Overview

Uniprot ID	A0A287AAY5
Protein Name	Afadin
Gene Name	AFDN
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1785	QGHEVSSKVKASRRL
660	SPAERTHKVIAIVNK

Function

Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions

Protein Sequence

10 MSAGARDEER 20 RKLADIIQHW 30 NANRLDLFEI 40 SQPTEDLEFH 50 GVMRFYFQDK 60 AAGNFATKCI 70 RVSSTATTQD 80 VIETLAEKFR 90 PDMRMLSSPK 100 YSLYEVHVSG 110 EERRLDIDEK 120 PLVVQLNWNK 130 DDREGRFVLK 140 NENDAAPPKK 150 AQSNGPEKQE 160 KEGVIQNFKR 170 TLSKKEKKEK 180 KKREKEAMRQ 190 ASDKDDRPFH 200 GEDTENSRLA 210 AEVYKDMPET 220 SFTRTISNPE 230 VVMKRRRQQK 240 LEKRMQEFRS 250 SDGRPDSGGT 260 LRIYADSLKP 270 NIPYKTILLS 280 TTDPADFAVA 290 EALEKYGLEK 300 ENPKDYCIAR 310 VMLPPGAQHS 320 DEKGAKEIIL 330 DDDECPLQIF 340 REWPGDKGML 350 VFQLKRRPPE 360 HIPKKSKKHA 370 EGKPPKGKER 380 PDGSGYGSAL 390 PPEKLPYLVE 400 LSPGETGQVC 410 ALSWTDGSDS 420 RDKPKLYRLQ 430 LSVTEVGTEK 440 FDDSSIQLFG 450 SGIQPHHCDL 460 TNMDGVVTVT 470 PRSVDAETYV 480 EGQRISETTM 490 LQSGVKVQFG 500 ASHVFKFVDP 510 SQDHALAKRP 520 GDGGLAVKGP 530 RHKPGIVQET 540 AFDLGGDVHG 550 GTAVASSKGS 560 ARPDGDRAPS 570 ASSSAERGMV 580 KPMVRMEPPQ 590 EPRRQDTRPQ 600 DAAGPELTLP 610 ASIEFRESAE 620 DSFLSAIINY 630 TNSSTVHFKL 640 SPTYVLYMAC 650 RHVLSSQYRP 660 DVSPAERTHK 670 VIAIVNKMVS 680 MMDGVIQKQK 690 NIAGALAFWM 700 ANASELLNFI 710 KQDRDLSRIT 720 LDAQDVLAHL 730 VQMAFKYLVH 740 CLQSELNNYM 750 PAFLDDPEEN 760 SLQRPKIEDV 770 LHTLTGAMSL 780 LRRCRVNAAL 790 TIQLFSQLFH 800 FINMWLFNRL 810 LTDPESGLCS 820 HYWGAIVRQQ 830 LGHVEAWAEK 840 QGLELAADCH 850 LSRVVQATTL 860 LTMDKYAPED 870 AAGINSTCFK 880 LNSLQLQALL 890 HNYHCAPDEP 900 LVPPDLIESV 910 VAVAENTADE 920 LARSDGREVR 930 LEEDPDLQLP 940 FLLPEDGYSC 950 DVVRNIPNGL 960 QEFLDPLCQR 970 GFCRLTPQPR 980 SPGSWTIHFE 990 GAEYESRLAR 1000 ESTELAQPLR 1010 KEPEVITVTL 1020 KKQNGMGLSI 1030 VAAKGAGQDK 1040 LGIYVKSVVR 1050 GGAADVDGRL 1060 AAGDQLLSVD 1070 GRSLVGLSQE 1080 RAAELMTRTS 1090 SVVTLEVAKQ 1100 GAIYHGLATL 1110 LNQPSPMMQR 1120 ISDRRGSGKP 1130 RPKSEGFELY 1140 NNSAQNGSPE 1150 SPPLPWAEYS 1160 EPKKLPGDER 1170 LTKNRADHRS 1180 SPNVANQPPS 1190 PGGKGAHAAG 1200 TAAKITSVST 1210 GNLCTEEQTP 1220 PPGTEAYPIP 1230 TQAYPREYFT 1240 FPASRSQDRV 1250 VPPQSQWPSY 1260 EEKPHADSSH 1270 SSLAVQRVTR 1280 SQEELREDAG 1290 AYPLHRMEAV 1300 MDRKSDSDMW 1310 VAQSSSMGSS 1320 ASSQEHLDPS 1330 SKAGTPASTL 1340 TKSGPGRWKT 1350 PAVLQPAPGP 1360 QPLRTDLPTH 1370 YAGDVDGVPV 1380 DLPLPPPPAA 1390 AGQGLAGGQG 1400 AAERKKREEQ 1410 QRWYEKEKAR 1420 LEEERERKRR 1430 EQERKLGQMR 1440 SQALLPAPLS 1450 PGATKPAAPG 1460 PQDTVIRELQ 1470 PQQQPRTIER 1480 RDLQYITVSR 1490 EELSAGDSLS 1500 PDPWKRDARE 1510 KLEKQQQMHV 1520 VDLLSREIHE 1530 LQSKAERSAE 1540 ESGRLRKLML 1550 EWQFQKRLQE 1560 SKQKDEDDDE 1570 EEDDDVDTML 1580 IMQRLEAERR 1590 ARVKGRPACG 1600 QLQDEERRRQ 1610 QQLEEMRQRE 1620 AEERARHEEE 1630 RRRQEEERLK 1640 REAEEKRRQE 1650 EGYYSRLEAE 1660 RRRQHEEAER 1670 RLLEPEEPGL 1680 GRPPLPRGYE 1690 PPGPAPPPPP 1700 QRAASYLQAQ 1710 VLSPDSLYTA 1720 KFVAYDDDDE 1730 EEDGPAGPAS 1740 YMGSTGTLMG 1750 AHDGSRDPRE 1760 TLSKSQDADV 1770 PGGPESLTFR 1780 ERQRLFSQGH 1790 EVSSKVKASR 1800 RLTELENELN TK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0005737	cytoplasm
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0034330	cell junction organization
Biological Process	GO:0007165	signal transduction

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.