Search Results
Overview
| Uniprot ID | A0A287AB49 |
|---|---|
| Protein Name | Diphosphomevalonate decarboxylase |
| Gene Name | MVD |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 230 | ALLRFRAKALVPARM |
| 58 | TTTAAISKDFTKDRI |
Function
Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis
Protein Sequence
10
MASEQQPVVV
20
TCTAPVNIAV
30
IKYWGKRDEE
40
LILPINSSLS
50
VTLHQHQLKT
60
TTTAAISKDF
70
TKDRIWLNGR
80
EEDVGQPRIQ
90
ACLREIRRLA
100
RKRKSDGDED
110
ALPLCLSYKV
120
HVASVNNFPT
130
AAGLASSAAG
140
FACLACALAR
150
VYGVEGDLSE
160
VARRGSGSAC
170
RSLYGGFVEW
180
QMGQRADGKD
190
SIAQQVAPES
200
HWPELRVLIL
210
VVSAEKKLMG
220
STAGMQTSVE
230
TSALLRFRAK
240
ALVPARMAEM
250
ARCIRERDFQ
260
AFGQLTMKDS
270
NQFHATCLDT
280
FPPISYLSDT
290
SQRVIRLVHR
300
FNAHHGCTKV
310
AYSFDAGPNA
320
VIFALDDTVP
330
EFVAAVQHSF
340
PPEPNGDKFL
350
QGLPVEPALL
360
SDELKAALGT
370
DPTPGGIRYI
380
IATQVGPGPQ
390
VLDDPGAHLL
400
GPDGLPKLAS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004163 | diphosphomevalonate decarboxylase activity |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0033489 | cholesterol biosynthetic process via desmosterol |
| Biological Process | GO:0033490 | cholesterol biosynthetic process via lathosterol |
| Biological Process | GO:0010142 | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0033386 | geranylgeranyl diphosphate biosynthetic process |
| Biological Process | GO:0019287 | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0036197 | zymosterol biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.