Search Results
Overview
| Uniprot ID | A0A287AB56 |
|---|---|
| Protein Name | Pre-mRNA-splicing factor RBM22 |
| Gene Name | RBM22 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 283 | NGRRLNVKWGRSQAA |
| 49 | GVRMRFKKTEVCQTC |
Function
Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses
Protein Sequence
10
MATSLGSNTY
20
NRQNWEDATK
30
EKYGKECKIC
40
ARPFTVFRWC
50
PGVRMRFKKT
60
EVCQTCSKLK
70
NVCQTCLLDL
80
EYGLPIQVRD
90
AGLSFKDDMP
100
KSDVNKEYYT
110
QNMEREISNS
120
DGTRPVGMLG
130
KATSTSDMLL
140
KLARTTPYYK
150
RNRPHICSFW
160
VKGECKRGEE
170
CPYRHEKPTD
180
PDDPLADQNI
190
KDRYYGINDP
200
VADKLLKRAS
210
TMPRLDPPED
220
KTITTLYVGG
230
LGDTIAETDL
240
RNHFYQFGEI
250
RTVTVVQRQQ
260
CAFIQFATRQ
270
AAEVAAEKSF
280
NKLIVNGRRL
290
NVKWGRSQAA
300
RGKEKEKDGT
310
TDSGIKLEPV
320
PGLPGALPPP
330
PAAEEEASAN
340
YFNLPPSGPP
350
AVVNIALPPP
360
PGIAPPPPPG
370
FGPHMFHPMG
380
PPPPFMRAPG
390
PIHYPSQDPQ
400
RMGAHAGKHG
SP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005681 | spliceosomal complex |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006397 | mRNA processing |
| Biological Process | GO:0008380 | RNA splicing |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.