Overview
| Uniprot ID | A0A287AB66 |
|---|
| Protein Name | COP9 signalosome complex subunit 6 |
|---|
| Gene Name | COPS6 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 279 |
KMLHSRVKLILEYVK |
Function
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets, including SFN
Protein Sequence
10
MEKILGNDNA
20
RSLNSKLPKC
30
EENVLAQQRM
40
HVRTKPGAGP
50
TLAGAGEMAA
60
AAAANGTGGS
70
SGMEVDAAVV
80
PSVMASGVTG
90
SVSVALHPLV
100
ILNISDHWIR
110
MRSQEGRPMQ
120
VIGALIGKQE
130
GRNIEVMNSF
140
ELLSHTVEEK
150
IIIDKEYYYT
160
KEEQFKQVFK
170
ELEFLGWYTT
180
GGPPDPSDIH
190
VHKQVCEIIE
200
SPLFLKLNPM
210
TKHTDLPVSV
220
FESVIDIING
230
EATMLFAELT
240
YTLATEEAER
250
IGVDHVARMT
260
ATGSGENSTV
270
AEHLIAQHSA
280
IKMLHSRVKL
290
ILEYVKASEA
300
GEVPFNHEIL
310
REAYALCHCL
320
PVLSTDKFKT
330
DFYDQCNDVG
340
LMAYLGTITK
350
TCNTMNQFVN
360
KFNVLYDRQG
370
IGRRMRGLFF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0008180 |
COP9 signalosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0008237 |
metallopeptidase activity |
| Biological Process |
GO:0000338 |
protein deneddylation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.