Search Results

Overview

Uniprot IDA0A287ACK8
Protein NameProtein 4.1
Gene NameEPB41L2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
232 CDLEKRAKGQVLFDK
270 KNWVDPAKEIKRQLR
373 EKVAELYKTHRGLSP
451 KRSNFYIKVRPAELE
479 RAAKRLWKVCVEHHT
500 PEPPPKAKFLTLGSK
507 KFLTLGSKFRYSGRT
594 RDVRSLAKAPPVQYI
926 QRTEISTKEVPIVQT
980 THITKTVKGGISETR

Function

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase

Protein Sequence

10 MTTEVGSASE 20 VKKESDQLGA 30 DATKEKPKEV 40 AENQQNQSSD 50 PEEEKGSQSS 60 PPAESQSSSR 70 PQKKERDPSG 80 SRGISRFIPP 90 WLKKQKSYTL 100 VVAKDGGDKK 110 EPTQAVVEEQ 120 ILAKEESLPE 130 EGKQAKGDAA 140 EMALQKQQQI 150 KVDVKEEKPP 160 VSSLEMQPVE 170 EVSKEREEEK 180 GKEIQEDTLD 190 EAAKRETKEV 200 QTNELKAEKA 210 SQKATKKTKT 220 VQCKVTLLDG 230 TEYSCDLEKR 240 AKGQVLFDKV 250 CEHLNLLEKD 260 YFGLVFQENP 270 EQKNWVDPAK 280 EIKRQLRNLP 290 WLFTFNVKFY 300 PPDPSQLTED 310 ITRYFLCLQL 320 RQDIASGRLP 330 CSLMTHALLG 340 SYTLQAELGD 350 YDPEEHDSND 360 LSDFQFAPTQ 370 TKELEEKVAE 380 LYKTHRGLSP 390 AQADSQFLEN 400 AKRLSMYGVD 410 LHHAKDSEGV 420 DIKLGVCANG 430 LLIYKDRLRI 440 NRFAWPKILK 450 ISYKRSNFYI 460 KVRPAELEQF 470 ESTIGFKLPN 480 HRAAKRLWKV 490 CVEHHTFYRL 500 VSPEPPPKAK 510 FLTLGSKFRY 520 SGRTQAQTRQ 530 ASTLIDRPAP 540 HFERTSSKRV 550 SRSLDGAPVG 560 VVDQSLMKDF 570 AGPAGEVSAY 580 GPGVVSPAVV 590 QDGDGRRDVR 600 SLAKAPPVQY 610 IEGKAKMEEE 620 ETQLEEDLDK 630 AQEEILKHQA 640 SISELKRNFM 650 ESTPEPRPNE 660 WEKRRITPLS 670 LQTQGSKGDR 680 LFKDIFSMKE 690 KHQMAATRTV 700 EEKAQEADKK 710 RAPESEGPCA 720 GASDAVKSSH 730 ETLNVVEEKK 740 QAEVGKDERV 750 ITEEVNGKAL 760 APGRGPGEMR 770 KVEPGTQKDS 780 TSLSSESSPS 790 SESEDEDVGE 800 YRPHHQVTEG 810 TIREEQEEEE 820 EVEEAPGPAA 830 KVVEREDPVP 840 ATRPVTHAGA 850 NVSTVETVIQ 860 ENVVAPQIPT 870 EKSVNEGVKQ 880 DVREDPEDEP 890 QKVNGEVSHV 900 DIDVLPQVIC 910 CSEPPVVKTE 920 MVTISDASQR 930 TEISTKEVPI 940 VQTETKTITY 950 ESPQIDGGAG 960 GDSGTLLTAQ 970 TITSESVSTT 980 TTTHITKTVK 990 GGISETRIEK 1000 RIVITGDADI 1010 DHDQALAQAI 1020 REAREQHPDM 1030 SVTRVVVHKE TELEEGDE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005856 cytoskeleton
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0030866 cortical actin cytoskeleton organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.