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Overview

Uniprot IDA0A287AD42
Protein NameMethionine aminopeptidase 2
Gene NameMETAP2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
256 PKYDTLLKAVKDATN
259 DTLLKAVKDATNTGI
301 DGKTYQVKPIRNLNG
320 PYRIHAGKTVPIVKG
326 GKTVPIVKGGEATRM
46 RRKKKKTKGAATAGQ

Function

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)

Protein Sequence

10 MAGVEEAASS 20 GSHLNGDLDP 30 DDREEGAAST 40 AEEAAKKKRR 50 KKKKTKGAAT 60 AGQQEPEKES 70 GGSIDEVTRQ 80 LETQALDEKE 90 RDDDDEAKVQ 100 TDPPSVPICD 110 LYPNGVFPKG 120 QECEYPPTQD 130 GRTAAWRTTS 140 EEKKALDQAS 150 EEIWNDFREA 160 AEAHRQVRKY 170 VMSWIKPGMT 180 MIEICEKLED 190 CSRKLIKENG 200 LNAGLAFPTG 210 CSLNNCAAHY 220 TPNAGDTTVL 230 QYDDICKIDF 240 GTHISGRIID 250 CAFTVTFNPK 260 YDTLLKAVKD 270 ATNTGIKCAG 280 IDVRLCDVGE 290 AIQEVMESYE 300 VEIDGKTYQV 310 KPIRNLNGHS 320 IGPYRIHAGK 330 TVPIVKGGEA 340 TRMEEGEVYA 350 IETFGSTGKG 360 IVHDDMECSH 370 YMKNFDVGHV 380 PIRLPRTKHL 390 LNVINENFGT 400 LAFCRRWLDR 410 LGESKYLMAL 420 KNLCDLGIVD 430 PYPPLCDIKG 440 SYTAQFEHTI 450 LLRPTCKEVV SRGDDY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0004239 initiator methionyl aminopeptidase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0070006 metalloaminopeptidase activity
Biological Process GO:0006508 proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.