Search Results
Overview
| Uniprot ID | A0A287AD45 |
|---|---|
| Protein Name | Hypoxanthine phosphoribosyltransferase |
| Gene Name | HPRT1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 107 | TVDFIRLKSYCNDQS |
| 165 | QHNPKMVKVASLLVK |
| 219 | CVISETGKAKYKA** |
Function
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway
Protein Sequence
10
MLSLKQPCVF
20
LFQISDDEPG
30
YDLDLFCIPN
40
HYAEDLEKVF
50
IPHGLIMDRT
60
ERLARDVMKE
70
MGGHHIVALC
80
VLKGGYKFFA
90
DLLDYIKALN
100
RNSDRSIPMT
110
VDFIRLKSYC
120
NDQSTGDIKV
130
IGGDDLSTLT
140
GKVCILEGEK
150
DIIDTGKTMQ
160
TLLSLVKQHN
170
PKMVKVASLL
180
VKRTPRSVGY
190
RPDFVGFEIP
200
DKFVVGYALD
210
YNEYFRDLNH
220
VCVISETGKA
KYKA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0052657 | guanine phosphoribosyltransferase activity |
| Molecular Function | GO:0004422 | hypoxanthine phosphoribosyltransferase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Biological Process | GO:0044209 | AMP salvage |
| Biological Process | GO:0046038 | GMP catabolic process |
| Biological Process | GO:0032263 | GMP salvage |
| Biological Process | GO:0006178 | guanine salvage |
| Biological Process | GO:0043103 | hypoxanthine salvage |
| Biological Process | GO:0032264 | IMP salvage |
| Biological Process | GO:0045964 | positive regulation of dopamine metabolic process |
| Biological Process | GO:0051289 | protein homotetramerization |
| Biological Process | GO:0006166 | purine ribonucleoside salvage |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.