Search Results
Overview
| Uniprot ID | A0A287ADD4 |
|---|---|
| Protein Name | H/ACA ribonucleoprotein complex subunit DKC1 |
| Gene Name | DKC1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 144 | ERATRLVKSQQSAGK |
| 151 | KSQQSAGKEYVGIVR |
| 443 | QLVAEAAKTPKPRKR |
| 61 | LLLKNFDKLNVRTTH |
| 80 | PCGSNPLKREIGDYI |
Function
Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme
Protein Sequence
10
MADAEVLILP
20
KKHKKKKERK
30
SLPEEDVAEI
40
QHAEEFLIKP
50
ESKVAQLDTS
60
QWPLLLKNFD
70
KLNVRTTHYT
80
PLPCGSNPLK
90
REIGDYIRTG
100
FINLDKPSNP
110
SSHEVVAWIR
120
RILRVEKTGH
130
SGTLDPKVTG
140
CLIVCIERAT
150
RLVKSQQSAG
160
KEYVGIVRLH
170
NAIEGGTQLS
180
RALETLTGAL
190
FQRPPLIAAV
200
KRQLRVRTVY
210
ESKMIEFDPE
220
RRLGIFWVSC
230
EAGTYIRTLC
240
VHLGLLLGVG
250
GQMQELRRVR
260
SGVMSEKDHM
270
VTMHDVLDAQ
280
WLYDNHKDES
290
YLRRVVYPLE
300
KLLTSHKRLV
310
MKDSAVNAIC
320
YGAKIMLPGV
330
LRYEDGIEVN
340
QEIVVITTKG
350
EAICMAVALM
360
TTAVISTCDH
370
GVVAKIKRVI
380
MERDTYPRKW
390
GLGPKASQKR
400
LMIKQGLLDK
410
HGKPTDSTPA
420
AWTQDYVDYS
430
DPAKKEAVAE
440
AAKAPQLVAE
450
AAKTPKPRKR
460
ESESDETSPA
470
AAQLPKKEKK
480
KKKDKKPKAA
490
PEGAAEPGDG
500
DSDTTKKKKK
510
KKKIKVEVVS
E
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0015030 | Cajal body |
| Molecular Function | GO:0009982 | pseudouridine synthase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0031118 | rRNA pseudouridine synthesis |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.