Overview
| Uniprot ID | A0A287AE28 |
|---|
| Protein Name | CCR4-NOT transcription complex subunit 3 |
|---|
| Gene Name | CNOT3 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 125 |
TKTKAYSKEGLGLAQ |
Function
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity
Protein Sequence
10
MPRTSEKQLG
20
DGPGEGVVAS
30
VPGLRREAGF
40
LLEWAVGHPE
50
PHSGLDSLIP
60
QLHNAANANQ
70
KEKYEADLKK
80
EIKKLQRLRD
90
QIKTWVASNE
100
IKDKRQLIDN
110
RKLIETQMER
120
FKVVERETKT
130
KAYSKEGLGL
140
AQKVDPAQKE
150
KEEVGQWLTN
160
TIDTLNMQVD
170
QFESEVESLS
180
VQTRKKKGDK
190
DKQDRIEGLK
200
RHIEKHRYHV
210
RMLETILRML
220
DNDSILVDAI
230
RKIKDDVEYY
240
VDSSQDPDFE
250
ENEFLYDDLD
260
LEDIPQALVA
270
TSPPSHSHME
280
DEIFNQSSST
290
PTSTTSSSPI
300
PPSPANCTTE
310
NSEDDKKRGR
320
STDSEVSQSP
330
AKNGSKPVHS
340
NQHPQSPAVP
350
PSYPSGPPPT
360
ASALSTTPGN
370
NGAPAPAAPA
380
SALGPKASPA
390
PSHNSGTPAP
400
YAQAVAPPAP
410
SGPSTAQPRP
420
PSVQPGGGGG
430
GGSGGGGGGG
440
SSNNSSGGGG
450
AGKQNGATSY
460
SSVVADSPAE
470
VALSSSGGNT
480
TSSQALGPPS
490
GPHNPPPSTS
500
KEPSAAAPTG
510
AGGVAPGSGN
520
NSGGPSLLVP
530
LPVNPPSSPT
540
PSFSEAKAAS
550
TLLNGPPQFS
560
AAPEIKAPEP
570
LSSLKSMAER
580
AAISSGIEDP
590
VPTLHLTERD
600
IILSSTSAPP
610
ASAQPPLQLS
620
EVNIPLSLGV
630
CPLGPVPLTK
640
EQLYQQAMEE
650
AAWHHMPHPS
660
DSERIRQYLP
670
RNPCPTPPYH
680
HQMPPPHSDT
690
VEFYQRLSTE
700
TLFFIFYYLE
710
GTKAQYLAAK
720
ALKKQSWRFH
730
TKYMMWFQRH
740
EEPKTITDEF
750
EQGTYIYFDY
760
EKWGQRKKEG
770
FTFEYRYLED
RDLQ
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0006417 |
regulation of translation |
| Biological Process |
GO:0031047 |
regulatory ncRNA-mediated gene silencing |
| Cellular Component |
GO:0030015 |
CCR4-NOT core complex |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000932 |
P-body |
| Biological Process |
GO:0007368 |
determination of left/right symmetry |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0000289 |
nuclear-transcribed mRNA poly(A) tail shortening |
| Biological Process |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
| Biological Process |
GO:0006355 |
regulation of DNA-templated transcription |
| Biological Process |
GO:2000036 |
regulation of stem cell population maintenance |
| Biological Process |
GO:0001829 |
trophectodermal cell differentiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.