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Overview

Uniprot ID	A0A287AEG0
Protein Name	Serine/threonine-protein kinase MRCK beta
Gene Name	CDC42BPB
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
1281	VRVADYKKVYQIELA

Function

Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation

Protein Sequence

10 MSAKVRLKKL 20 EQLLLDGPWR 30 NESALSVETL 40 LDVLVCLYTE 50 CSHSALRRDK 60 YVAEFLEWAK 70 PFTQLVKEMQ 80 LHREDFEIIK 90 VIGRGAFGEV 100 AVVRMKSTER 110 IYAMKILNKW 120 EMLKRAETAC 130 FREERDVLVN 140 GDSQWLTTLH 150 YAFQDENYLY 160 LVMDYYVGGD 170 LLTLLSKFED 180 RLPEDMARFY 190 IGEMVLAIDS 200 IHQLHYVHRD 210 IKPDNVLLDV 220 NGHIRLADFG 230 SCLKMNDDGT 240 VQSSVAVGTP 250 DYISPEILQA 260 MEDGMGRYGP 270 ECDWWSLGVC 280 MYEMLYGETP 290 FYAESLVETY 300 GKIMNHEERF 310 QFPSHVTDVS 320 EEAKDLIQRL 330 ICSRERRLGQ 340 NGVEDFKKHA 350 FFQGLNWETI 360 RNLEAPYIPD 370 VSSPSDTSNF 380 DVDDDVLRNV 390 EILPPASHTG 400 FSGLHLPFIG 410 FTFTTESCFS 420 DRGSLKSIMQ 430 SSTLTKDEGL 440 QRDLENSLQV 450 EAYERRIRRL 460 EQERLELSRK 470 LQEATQTVQS 480 FHGAARTLGS 490 AARDKEIKKL 500 NEEIERLKNK 510 IAESNKLERQ 520 LEDTVTLRQE 530 QEDSTHRLKG 540 LEKQYRAVRQ 550 EKEDFHKQLI 560 EASERLKSQA 570 RELKDAHQQR 580 KLALQEFSEL 590 NERMAELRSQ 600 KQKVSRQLRD 610 REEEVEAALQ 620 KIDALRQEVR 630 RADKCRKELE 640 AQLEDAVAEA 650 SKERKLREHS 660 ENFSKQIESE 670 LEALKMKQGG 680 RGPGAALEHQ 690 QEISRIKSEL 700 EKKVLFYEEE 710 LVRREASHVL 720 ELKTVKKEVH 730 DSEGHQLALQ 740 KEVLVLKDKL 750 EKSKRERHSE 760 LEEAVGTVKD 770 KYERERAVLS 780 EENKKLTAEN 790 EKLCAFVDKL 800 TAQNRQLEDE 810 LQDLAAKKES 820 VAHWEAQIAE 830 IIQWVSDEKD 840 ARGYLQALAS 850 KMTEELEALR 860 SSSLGSRTLD 870 PLWKVRRSQK 880 LDMSARLELQ 890 SALEAEIRAK 900 QLVQEELRKV 910 KDMNLSFESK 920 LKDSEAKNRE 930 LLEEMEILKK 940 KMEEKFRTDA 950 GLKLPDFQDS 960 IFEYFNTAPL 970 AHDLTFRASS 980 ASEQETQAAK 990 PEAMPPSSVA 1000 ASTEQQEDVA 1010 RAPQRPPTVP 1020 LPSTQALALA 1030 GPKPKAHQFS 1040 IKSFSSPTQC 1050 SHCTSLMVGL 1060 IRQGYACDVC 1070 SFACHVSCRD 1080 SAPQVCPIPP 1090 EQSKRPLGVD 1100 VQRGIGTAYK 1110 GYVKVPKPTG 1120 VKKGWQRAYA 1130 VVCDCKLFLY 1140 DLPEGKSTQP 1150 GVVASQVLDL 1160 RDEEFSVSSV 1170 LASDVIHASR 1180 RDIPCIFRVT 1190 ASLLGTPSKT 1200 SSLLILTENE 1210 NEKRKWVGIL 1220 EGLQSILQKN 1230 RLRSQVVHSP 1240 QEAYDSSLPL 1250 IKAVLAAAIL 1260 DADRIAVGLE 1270 EGLYVVEVTR 1280 DVIVRVADYK 1290 KVYQIELAPK 1300 EKVAALLCGR 1310 NHHVHLCPWS 1320 SFDGAEGTVD 1330 IKLPETKGCQ 1340 LIATGAPKKS 1350 SPTCLFVAVK 1360 RLVLCYEMQR 1370 TKPFHRKLSE 1380 LAAPGPVQWM 1390 AVLKDKLCQS 1400 FDALCAVELQ 1410 SEEYLLCFSH 1420 MGLYVDPQGR 1430 RSRMQELMWP 1440 AAPVACSCSP 1450 SHVTVYSDYG 1460 VDVFDARSME 1470 WVQTIGLRRI 1480 RPLNSEGSLN 1490 LLNCEPPRLI 1500 YFKSKFAGPA 1510 LNVPDTSDNS 1520 KKQMLRTRSK 1530 RRFVFKVPEE 1540 ERLQQRREML 1550 RDPELRSRMI 1560 SNPTNFNHVA 1570 HMGPGDGMQV 1580 LMDLPLSAVP 1590 PSQEERPGPA 1600 PASLSRQPPP 1610 RNKPYVSWPS 1620 SGGSEPGVAV 1630 PLRSMSDPDQ 1640 DFDKEPDSDS 1650 TKHSTPSNSS 1660 NPSGPPSPNS 1670 PHRSQLPLEG LEQPSYDA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0042641	actomyosin
Cellular Component	GO:0070161	anchoring junction
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0030027	lamellipodium
Cellular Component	GO:0005886	plasma membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0031032	actomyosin structure organization
Biological Process	GO:0016477	cell migration

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.