Search Results
Overview
| Uniprot ID | A0A287AEK2 |
|---|---|
| Protein Name | cAMP-dependent protein kinase type II-alpha regulatory subunit |
| Gene Name | PRKAR2A |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 175 | TYDILVTKDNQTRSV |
| 228 | TFRRIIVKNNAKKRK |
| 265 | IVDVIGEKIYKDGER |
| 303 | KSKTKANKDGGNQEV |
| 317 | VEIARCHKGQYFGEL |
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase
Protein Sequence
10
MSHIQIPPGL
20
TELLQGYTVE
30
VLRRQPPDLV
40
DFAVDYFTRL
50
REARSRASTP
60
PAAPPSGSQD
70
LEPSSGLVTD
80
AIADSESEDD
90
EDLDVCAETY
100
NPDEEEEDTD
110
PRVIHPKTDQ
120
QRCRLQEACK
130
DILLFKNLDQ
140
EQLSQVLDAM
150
FERTVKVDEH
160
VIDQGDDGDN
170
FYVIERGTYD
180
ILVTKDNQTR
190
SVGQYDNHGS
200
FGELALMYNT
210
PRAATIVATS
220
EGSLWGLDRV
230
TFRRIIVKNN
240
AKKRKMFESF
250
IESVPLLKSL
260
EVSERMKIVD
270
VIGEKIYKDG
280
ERIITQGEKA
290
DSFYIIESGE
300
VSILIKSKTK
310
ANKDGGNQEV
320
EIARCHKGQY
330
FGELALVTNK
340
PRAASAYAVG
350
DVKCLVMDVQ
360
AFERLLGPCM
370
DIMKRNISHY
380
EEQLVKMFGS
SMDLIDPGQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005930 | axoneme |
| Molecular Function | GO:0030552 | cAMP binding |
| Molecular Function | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0034236 | protein kinase A catalytic subunit binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0141162 | negative regulation of cAMP/PKA signal transduction |
| Cellular Component | GO:0005952 | cAMP-dependent protein kinase complex |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0031588 | nucleotide-activated protein kinase complex |
| Cellular Component | GO:0044853 | plasma membrane raft |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.