Search Results

Overview

Uniprot IDA0A287AEM4
Protein NameCLIP-associating protein 1
Gene NameCLASP2
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
1336 TIRALALKVLREILR
1487 KLLNLYIKRAQTGSG
240 ILSVCKDKSFDDEES

Function

Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle

Protein Sequence

10 MEPRSMEYFS 20 AQVQQKDVGG 30 RLQVGQELLL 40 YLGVPGAIPD 50 LEENLGCLGK 60 TVDALTGWVG 70 SSNYRVSLMG 80 LEILSAFVDR 90 LSTRFKSYVA 100 MVIVALIDRL 110 GDAKDKVRDK 120 TQALILKLMD 130 QVAPPMYIWE 140 QLASGFKHKN 150 SQSREGVCLC 160 LIETLNVFGA 170 QPLVLSKLVP 180 HLCILFGDYN 190 SQVRDAATLA 200 IVEIYRHVGD 210 KVRMDLYKKG 220 IPPARLETIL 230 AKFDEVQNSG 240 GMILSVCKDK 250 SFDDEESVDG 260 NRPSSAASAF 270 KVPAPKTSGN 280 PVNSARKPGS 290 AGGPKVGAGA 300 SKEGGAGAVD 310 EDDFIKAFTD 320 VPSIQIYSSR 330 ELEETLNKIR 340 EILSDDKHDW 350 DQRANALKKI 360 RSLLVAGAAQ 370 YDCFFQHLRL 380 LDGALKLSAK 390 DLRSQVVREA 400 CITVAHLSTV 410 LGNKFDHGAE 420 AIVPTLFNLV 430 PNSAKVMATS 440 GCAAIRFIIR 450 HTHVPRLIPL 460 ITSNCTSKSV 470 PVRRRSFEFL 480 DLLLQEWQTH 490 SLERHAAVLV 500 ETIKKGIHDA 510 DAEARVEARK 520 TYMGLRNHFP 530 GEAETLYNSL 540 EPSYQKSLQT 550 YLKSSGSVAS 560 LPQSDRSSSS 570 SQESLNRPFS 580 SKWSTANPST 590 VAGRVSTGSS 600 KANSLPGSLQ 610 RSRSDIDVNA 620 AAGAKAHHAA 630 GQSVRSGRLG 640 AGALNPGSYA 650 SLGTASDDGR 660 VRAKLSAPLA 670 GMGSAKTDTR 680 GRSRTKMVSQ 690 SQPGSRSGSP 700 GRVLTTTALS 710 TVSSGVQRVL 720 VNSASAQKRS 730 KIPRSQGCSR 740 EASPSRLSVA 750 RSSRIPRPSV 760 SQGCSREASR 770 ESSRDTSPVR 780 SFQPLGPGYG 790 ISQSSRLSSS 800 VSAMRVLNTG 810 SDVEEAVADA 820 LLLGDIRTKK 830 KPARRRYESY 840 GMHSDDDANS 850 DASSACSERS 860 YSSRNGSIPT 870 YMRQTEDVAE 880 VLNRCASSNW 890 SERKEGLLGL 900 QNLLKNQRTL 910 SRVELKRLCE 920 IFTRMFADPH 930 GKVFSMFLET 940 LVDFIQVHKD 950 DLQDWLFVLL 960 TQLLKKMGAD 970 LLGSVQAKVQ 980 KALDVTRESF 990 PNDLQFNILM 1000 RFTVDQTQTP 1010 SLKVKVAILK 1020 YIETLAKQMD 1030 PGDFINSSET 1040 RLAVSRVITW 1050 TTEPKSSDVR 1060 KAAQSVLISL 1070 FELNTPEFTM 1080 LLGALPKTFQ 1090 DGATKLLHNH 1100 LRNTGNGTQG 1110 SMGSPLTRPT 1120 PRSPANWSSP 1130 LTSPTNTSQN 1140 TLSPSAFDYD 1150 TENMNSEDIY 1160 SSLRGVTEAI 1170 QNFSFRSQED 1180 MNEPLKRESK 1190 KDDVDSMCGG 1200 PGMSDPRAGG 1210 DATDSSQTAL 1220 DNKASLLHSM 1230 PAHSSPRSRD 1240 YNPYNYSDSI 1250 SLFNKSALKE 1260 AMFDDDADQF 1270 PDDLSLDHSD 1280 LVAELLKELS 1290 NHNERVEERK 1300 IALYELMKLT 1310 QEESFSVWDE 1320 HFKTILLLLL 1330 ETLGDKEPTI 1340 RALALKVLRE 1350 ILRHQPARFK 1360 NYAELTVMKT 1370 LEAHKDPHKE 1380 VVRSAEEAAS 1390 VLATSISPEQ 1400 CIKVLCPIIQ 1410 TADYPINLAA 1420 IKMQTKVIER 1430 VSKETLNLLL 1440 PEIMPGLIQG 1450 YDNSESSVRK 1460 ACVFCLVAVH 1470 AVIGDELKPH 1480 LSQLTGSKMK 1490 LLNLYIKRAQ 1500 TGSGGGDPTT DVSGQS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005819 spindle
Molecular Function GO:0008017 microtubule binding
Biological Process GO:0051301 cell division
Biological Process GO:0030010 establishment of cell polarity
Biological Process GO:0007026 negative regulation of microtubule depolymerization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.