Search Results
Overview
| Uniprot ID | A0A287AES5 |
|---|---|
| Protein Name | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial |
| Gene Name | PCK2 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 141 | DVARVESKTVIVTPS |
| 294 | GGNSLLGKKCFALRI |
Function
Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Can play an active role in glyceroneogenesis and gluconeogenesis. Also acts as a serine/threonine-protein kinase: phosphorylates and activates ACSL4, thereby promoting ferroptosis
Protein Sequence
10
MAAMYRPGLR
20
CNSCAPGWAR
30
STRALGTRVH
40
EPLGIELPEK
50
GRRLSWHGLS
60
SWGWSSRRSI
70
QALRVLNGDL
80
GQLPAGVRDF
90
VERSARLCQP
100
EGIHICDGTE
110
AENTATLALL
120
EQQGLIRKLP
130
KYNNCWLART
140
DPKDVARVES
150
KTVIVTPSQR
160
DTVPLPAGGA
170
RGQLGNWMSP
180
AEFQQAVDER
190
FPGCMQGRTM
200
YVLPFSMGPV
210
GSPLSRIGVQ
220
LTDSAYVVAS
230
MRIMTRLGKP
240
VLQALGDGDF
250
VKCLHSVGQP
260
LTGQGEPVSQ
270
WPCNPEKTLI
280
GHVPDQREIV
290
SFGSGYGGNS
300
LLGKKCFALR
310
IASRLARDEG
320
WLAEHMLILG
330
ITNPAGKKRY
340
VAAAFPSACG
350
KTNLAMMRPA
360
LPGWKVECVG
370
DDIAWMRFDS
380
DGQLRAINPE
390
NGFFGVAPGT
400
SATTNPNAMA
410
TIQSNTLFTN
420
VAETSDGGVY
430
WEGIDQPLPP
440
GVTVTSWLGK
450
PWKPGDKEPC
460
AHPNSRFCAP
470
ARQCPIMDPA
480
WEAPEGVPID
490
AIIFGGRRPK
500
GVPLVYEAFS
510
WRHGVFVGSA
520
MRSESTAAAE
530
HKGKVIMHDP
540
FAMRPFFGYN
550
FGRYLEHWLS
560
MEGRKGARLP
570
RIFHVNWFRR
580
DEAGHFLWPG
590
FGENARVLDW
600
ICRRLEQEDS
610
ARETPIGLVP
620
KEGALDLRGL
630
GAIDTTQLFS
640
IPKDFWEQEV
650
RDIRSYLTEQ
660
VNQDLPKEVL
670
AELEALEGRV
RRM
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0030145 | manganese ion binding |
| Molecular Function | GO:0004613 | phosphoenolpyruvate carboxykinase (GTP) activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0071549 | cellular response to dexamethasone stimulus |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0006094 | gluconeogenesis |
| Biological Process | GO:0046327 | glycerol biosynthetic process from pyruvate |
| Biological Process | GO:0070365 | hepatocyte differentiation |
| Biological Process | GO:0006107 | oxaloacetate metabolic process |
| Biological Process | GO:0160020 | positive regulation of ferroptosis |
| Biological Process | GO:0042594 | response to starvation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.