Search Results
Overview
| Uniprot ID | A0A287AEW7 |
|---|---|
| Protein Name | Twinfilin-1 |
| Gene Name | TWF1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 145 | DVSLHGYKKYLLSQS |
| 39 | NGKYRLLKISIENEK |
| 46 | KISIENEKLVIGSCR |
Function
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles
Protein Sequence
10
MSCLPSTVWC
20
CSRTLPQTSS
30
EDVKDIFARA
40
RNGKYRLLKI
50
SIENEKLVIG
60
SCRQPSDSWD
70
KDYDSFVLPM
80
LEDKQPCYIL
90
FRLDSQNAQG
100
YEWIFIAWSP
110
DHSHVRQKML
120
YAATRATLKK
130
EFGGGHIKDE
140
VFGTVKEDVS
150
LHGYKKYLLS
160
QSSPAPLTAA
170
EEELRQIKIN
180
EVQTDVSVDT
190
KHQTLQGVAF
200
PISREAFQAL
210
EKLNNRQLNY
220
VQLEIDIKNE
230
VIILANTVNT
240
ELKDLPKRIP
250
KDSARYHFFL
260
YKHSHEGDYL
270
DVFLSVCSLG
280
LSCSFMRERM
290
LYSSCKSPLL
300
EIVERQLQMD
310
VIRKIEIDNG
320
DELTADFLYE
330
EVHPKQHAHK
340
QSFAKPKGPS
350
GKRGIRRLIR
360
GPAETEATTD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005856 | cytoskeleton |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0030837 | negative regulation of actin filament polymerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.