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Overview

Uniprot ID	A0A287AEY1
Protein Name	S1 RNA-binding domain-containing protein 1
Gene Name	SRBD1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
184	QPPLKKVKTETCPQG

Function

DNA- and histone-binding protein that localizes to the central axes of mitotic chromosomes. Promotes chromosome segregation by facilitating TOP2A recruitment to mitotic chromosomes, thereby preventing anaphase failure. During prophase, safeguards the decatenation process to avoid the formation of difficult-to-resolve DNA structures, preventing chromosome missegregation. Also contributes to the regulation of nucleus pulposus cell senescence

Protein Sequence

10 MSSLPRRAKV 20 KVQTVVSKDE 30 FSSLSELSSA 40 SEDDKEDSAW 50 EPQKKVPRSR 60 KPPVSKESKP 70 KRAPRVKKTP 80 LQSRDGVEDV 90 AVKEELNSSV 100 AIADVDMEDR 110 KNKLDTVQGL 120 KTARMKRKNS 130 TQSPSARRTK 140 KLKADKDISK 150 ASSLESGSNS 160 TETPSTSATW 170 EGGSKKEEKE 180 DDVTCGQPPL 190 KKVKTETCPQ 200 GQPVRFPANA 210 SSIKEEVEMN 220 WDIVQVLSER 230 TNIELWVCAN 240 IIRLFNDDNT 250 IPFIIRYRKE 260 LINNLDADSL 270 REVRQTLEEL 280 RAVAKKTHST 290 IQKIKKEGKM 300 SECLLKALLN 310 CKTFEELEHV 320 SAPYKTGSKG 330 TKAQRAKQLG 340 LEGAARTLLE 350 NPGELNLLSY 360 IRPNVKGLSA 370 LQDIETGVQH 380 ILADMIAKDR 390 DTLDFIRKLC 400 QNRYICIQSS 410 LAKVSSKKVN 420 EKDVDKFQLY 430 QNFSCNIRNI 440 QHHQILAINR 450 GENLKILTVK 460 VNISDGVKNE 470 FCRWCIQNRW 480 RPRGFARPEL 490 MKILYSSLDD 500 SFKRLIYPLL 510 CREFRAKLTS 520 DAEKESVMMF 530 GRNLRQLLLT 540 SPVPGRTLMG 550 VDPGYKHGCK 560 LAIISPTSQI 570 LHTDVVYLHC 580 GQGFREAEKI 590 KRLLLNFNCS 600 TVVIGNGTAC 610 RETEAYFADL 620 IMKNYFAPLD 630 VVYCIVSEAG 640 ASIYSVSPEA 650 NKEMPGLDPN 660 LRSAVSIARR 670 VQDPLAELVK 680 IEPKHIGVGM 690 YQHDVSQTLL 700 KATLDSVVEE 710 CVSFVGVDIN 720 ICSEVLLRHI 730 AGLNANRAKN 740 IIEWREKNGP 750 FINREQLKKV 760 KGLGPKSFQQ 770 CAGFIRVNQD 780 YIRTFCSSQQ 790 TESAGEIQGV 800 AVTSSAGVEV 810 TNEKPGKKKS 820 KTAVNVVLKP 830 NPLDQTCIHP 840 ESYDIAMRFL 850 SFIGGTLNEI 860 GKPEMQQKIN 870 SFLEKEGIEK 880 IAERLQTTVH 890 TLQVIIDGLS 900 QPETFDFRTD 910 FDKPDFKRSI 920 VCLEDLQVGT 930 VLTGKVENAT 940 LFGIFVDIGV 950 GRSGLIPIRN 960 VTEAKLSKTK 970 KRRSLGLGPG 980 ERVEVQVLNI 990 DIPRSRITLD LIRVL

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0003735	structural constituent of ribosome
Biological Process	GO:0006139	nucleobase-containing compound metabolic process
Biological Process	GO:0006412	translation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.