Search Results

Overview

Uniprot IDA0A287AF78
Protein NameProtein enabled homolog
Gene NameENAH
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
22 VYDDANKKWVPAGGS
52 TFRVVGRKIQDHQVV
66 VINCAIPKGLKYNQA
673 RRRRIAEKGSTIETE
69 CAIPKGLKYNQATQT
765 RKELTKLKEELIDAI

Function

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation

Protein Sequence

10 MSEQSICQAR 20 AAVMVYDDAN 30 KKWVPAGGST 40 GFSRVHIYHH 50 TGNNTFRVVG 60 RKIQDHQVVI 70 NCAIPKGLKY 80 NQATQTFHQW 90 RDARQVYGLN 100 FGSKEDANVF 110 ASAMMHALEV 120 LNSQEAVFYL 130 GPTLPRQNSQ 140 LPAQVQNGPS 150 QEELEIQRRQ 160 LQEQQRQKEL 170 ERERLERERM 180 ERERLERERL 190 ERERLERERL 200 EQEQLERERQ 210 ERERQERQER 220 LERERQERER 230 LERLERLDRE 240 RQERERQEQL 250 EREQLEWERE 260 RRVSSAAPSS 270 DSSLYNAPLP 280 EYASCQPPSA 290 PPPSYAKVIS 300 APVSDASPDY 310 AVVTALPPTS 320 TPPTPPLRHS 330 ATRFATSLGS 340 AFHPVLPHYA 350 TVPRPLNKGS 360 RPSSPVNTPS 370 PQPPAAKPCA 380 WAASNFSPLP 390 PSPPVMISSP 400 PGKAAGPRPV 410 LPVCVSSPGP 420 QMPPSPTAPS 430 GLLDSVPCPV 440 SPPPTSGPAP 450 PPPPPPLPSL 460 VPLSHCGSQA 470 SPPPSTPLAS 480 TPSSKPSVLP 490 SPSAAAPASV 500 ETPLNSVLGD 510 SSASEPGLQA 520 ASQPAETPAQ 530 QGIVLGPPAP 540 PPPPPLPPGP 550 AQASAILPPP 560 PGPPPPPPLP 570 SSGPPPPPPP 580 PPLPNQAPPP 590 PPPPPAPPLP 600 ASGFFSGSMS 610 EDNRPLTGLA 620 AAIAGAKLRK 630 VSRMEDGSFP 640 SGVNAASSKT 650 DTGRGNGPLP 660 LGGSGLMEEM 670 SALLARRRRI 680 AEKGSTIETE 690 QKEDKNEDSE 700 PQTSKASSTS 710 TPEPTRKPWE 720 RTNTMNGSKS 730 PVISRPKSAP 740 SSQPSANGVQ 750 TEGLDYDRLK 760 QDILDEMRKE 770 LTKLKEELID 780 AIRQELSKSN TA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030175 filopodium
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045202 synapse
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005522 profilin binding
Molecular Function GO:0017124 SH3 domain binding
Molecular Function GO:0050699 WW domain binding
Biological Process GO:0008154 actin polymerization or depolymerization
Biological Process GO:0070358 actin polymerization-dependent cell motility
Biological Process GO:0007411 axon guidance

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.