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Overview

Uniprot ID	A0A287AFT6
Protein Name	DNA polymerase alpha subunit B
Gene Name	POLA2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
108	TPETPLTKRSVSARS

Function

Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis

Protein Sequence

10 MAELCVLYGQ 20 NEEGMVGELI 30 AFCTSTRKDG 40 LTSEILNSFE 50 HEFLSRRWSK 60 ARPSASKDSG 70 HAGARDIVSI 80 QELIEVEEEE 90 ETLLNAYTTP 100 SKGSQKRAIT 110 TPETPLTKRS 120 VSARSPHQLL 130 SPSSFSPSAT 140 PSQKYSSRSN 150 RGEVVTSFGS 160 TQGVSWSGRG 170 GAGNISLKVL 180 GCPEPLTGSY 190 KSMFQKLSDI 200 REVLTCKIEE 210 LGSELKEHYK 220 IEAFTPVLVP 230 AQEPVTLLGQ 240 IGCDSNGKLN 250 HKSVILEGDR 260 EHSSGAQIPV 270 DLSELKEYSL 280 FPGQVVVMEG 290 INTTGRKLVA 300 TRLYEGVPLP 310 FHQPSEEDGD 320 SEQIMVLVAC 330 GPYTTSDSIA 340 FEPLLDLITV 350 INRDRPDVCI 360 LFGPFLDAKH 370 EQVESCLLTS 380 PFEDVFKQCL 390 RTIIEGTRSS 400 GSHLVFVPSL 410 RDVHREPVYP 420 QPPFSCSDLP 430 REDKKRVQFV 440 PEPCTLSVNG 450 MIFGLTSTDL 460 LFHMGAEEIS 470 SSSGTSDRFS 480 RILKHILTQR 490 SYYPLYPPQE 500 DVAIDYEHFY 510 AHAQLPVTPD 520 VFVAPSELRY 530 FVKDILGCIC 540 VNPGRLTKGQ 550 VGGTFGRLYL 560 RRQPAGDGRR 570 SPCAAAQVVR I

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005658	alpha DNA polymerase:primase complex
Molecular Function	GO:0003677	DNA binding
Biological Process	GO:0006270	DNA replication initiation
Biological Process	GO:0006269	DNA replication, synthesis of primer

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.