Overview
| Uniprot ID | A0A287AG37 |
|---|
| Protein Name | Ras GTPase-activating protein-binding protein 2 |
|---|
| Gene Name | G3BP2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 331 |
VELRINTKGVGGKLP |
Function
Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Plays an essential role in stress granule formation. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress. Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations
Protein Sequence
10
MVMEKPSPLL
20
VGREFVRQYY
30
TLLNKAPEYL
40
HRFYGRNSSY
50
VHGGVDASGK
60
PQEAVYGQND
70
IHHKVLSLNF
80
SECHTKIRHV
90
DAHATLSDGV
100
VVQVMGLLSN
110
SGQPERKFMQ
120
TFVLAPEGSV
130
PNKFYVHNDM
140
FRYEDEVFGD
150
SEPELDEESE
160
DEVEEEQEER
170
QPTPEPVQET
180
NSGYYEAHPV
190
TNGIEEPLEE
200
SSHEPEPEPE
210
SETKTEELKP
220
QVEEKNLEEL
230
EEKSTSPPPA
240
EPVSLPQEPP
250
KPRVETKPEV
260
QSQPPRVREQ
270
RPRERPGFPP
280
RGPRPGRGDI
290
EQNESDNRRI
300
IRYPDSHQLF
310
VGNLPHDIDE
320
NELKEFFMSF
330
GNVVELRINT
340
KGVGGKLPNF
350
GFVVFDDSEP
360
VQRILIAKPI
370
MFRGEVRLNV
380
EEKKTRAARE
390
RETRGGGDDR
400
RDIRRNDRGP
410
GGPRGVVGGG
420
MMRDRDGRGP
430
PPRGGMAQKL
440
GSGRGTGQME
GRFTGQRR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0010494 |
cytoplasmic stress granule |
| Molecular Function |
GO:0003723 |
RNA binding |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0051028 |
mRNA transport |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.