Overview
| Uniprot ID | A0A287AGL2 |
|---|
| Protein Name | cAMP-dependent protein kinase catalytic subunit beta |
|---|
| Gene Name | PRKACB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 24 |
KEFLAKAKEDFLKKW |
| 310 |
WIAIYQRKVEAPFIP |
| 93 |
IEHTLNEKRILQAVN |
Function
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR
Protein Sequence
10
MGNAATAKKG
20
GEVESVKEFL
30
AKAKEDFLKK
40
WENPAPNNAG
50
LEDFERKKTL
60
GTGSFGRVML
70
VKHKATEQYY
80
AMKILDKQKV
90
VKLKQIEHTL
100
NEKRILQAVN
110
FPFLVRLEYS
120
FKDNSNLYMV
130
MEYVPGGEMF
140
SHLRRIGRFS
150
EPHARFYAAQ
160
IVLTFEYLHS
170
LDLIYRDLKP
180
ENLLIDHQGY
190
IQVTDFGFAK
200
RVKGRTWTLC
210
GTPEYLAPEI
220
ILSKGYNKAV
230
DWWALGVLIY
240
EMAAGYPPFF
250
ADQPIQIYEK
260
IVSGKVRFPS
270
HFSSDLKDLL
280
RNLLQVDLTK
290
RFGNLKNGVS
300
DIKTHKWFAT
310
TDWIAIYQRK
320
VEAPFIPKFR
330
GSGDTSNFDD
340
YEEEDIRVSI
350
TEKCGKEFCE
F
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0004691 |
cAMP-dependent protein kinase activity |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.