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Overview

Uniprot ID	A0A287AGU2
Protein Name	ATP synthase subunit alpha
Gene Name	ATP5F1A
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
123	FGNDKLIKEGDIVKR
129	IKEGDIVKRTGAIVD
158	LGNAIDGKGPIGSKT
164	GKGPIGSKTRRRVGL
172	TRRRVGLKAPGIIPR
215	IGDRQTGKTSIAIDT
227	IDTIINQKRFNDGTD
236	FNDGTDEKKKLYCIY
258	STVAQLVKRLTDADA
302	EYFRDNGKHALIIYD
313	IIYDDLSKQAVAYRQ
495	GVRGYLDKLEPSKIT
522	QHQALLGKIRADGKI
528	GKIRADGKISEETDA
536	ISEETDAKLKEIVTN

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane

Protein Sequence

10 MISGPLKIMT 20 ADLLKGMVSK 30 NALGSSFVAA 40 RNLHASNTRL 50 QKTGTAEVSS 60 ILEERILGAD 70 TSVDLEETGR 80 VLSIGDGIAR 90 VHGLRNVQAE 100 EMVEFSSGLK 110 GMSLNLEPDN 120 VGVVVFGNDK 130 LIKEGDIVKR 140 TGAIVDVPVG 150 EELLGRVVDA 160 LGNAIDGKGP 170 IGSKTRRRVG 180 LKAPGIIPRI 190 SVREPMQTGI 200 KAVDSLVPIG 210 RGQRELIIGD 220 RQTGKTSIAI 230 DTIINQKRFN 240 DGTDEKKKLY 250 CIYVAIGQKR 260 STVAQLVKRL 270 TDADAMKYTI 280 VVSATASDAA 290 PLQYLAPYSG 300 CSMGEYFRDN 310 GKHALIIYDD 320 LSKQAVAYRQ 330 MSLLLRRPPG 340 REAYPGDVFY 350 LHSRLLERAA 360 KMNDAFGGGS 370 LTALPVIETQ 380 AGDVSAYIPT 390 NVISITDGQI 400 FLETELFYKG 410 IRPAINVGLS 420 VSRVGSAAQT 430 RAMKQVAGTM 440 KLELAQYREV 450 AAFAQFGSDL 460 DAATQQLLSR 470 GVRLTELLKQ 480 GQYAPMAIEE 490 QVAVIYAGVR 500 GYLDKLEPSK 510 ITKFENAFLS 520 HVISQHQALL 530 GKIRADGKIS 540 EETDAKLKEI 550 VTNFLAGFEA

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0045259	proton-transporting ATP synthase complex
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.