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Overview

Uniprot ID	A0A287AH16
Protein Name	Rap1 GTPase-GDP dissociation stimulator 1
Gene Name	RAP1GDS1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
313	QKLFEGGKGNVFQRV
394	LAIPVVNKAKMLSAG
589	KLRGHENKSVAQQAS

Function

Acts as a GEF (guanine nucleotide exchange factor) for prenylated RHOA. Acts as a GEF for RHOC. Chaperones the downstream trafficking and/or processing of small newly prenylated GTPases. Escorts RAC1 to the nucleus

Protein Sequence

10 DNLSDTLKKL 20 KITAVDRTDD 30 SLEGCLDCLL 40 QALAQNNTET 50 SEKIQGSGIL 60 HLFSSLLIPQ 70 SSCTAKVANI 80 IAELAKNEFM 90 RIPCVDAGLI 100 SPLVQLLNSK 110 DQEVLLQTGR 120 ALGNICYDSH 130 EGRSAVDQAG 140 GAQIVVDHLR 150 SLCSITDPAN 160 EKLLTVFCGM 170 LMNYSNENDS 180 LQAQLINMGV 190 IPTLVKLLGI 200 HCQNAALTEM 210 CLVAFGNLAE 220 LESSKEQFAS 230 TNIAEELVKL 240 FKKQIEHDKR 250 EMIFEVLAPL 260 AENDAIKLQL 270 VEAGLVECLL 280 EIVQQKVDSD 290 KEEDIAELKT 300 ASDLMVLLLL 310 GDESMQKLFE 320 GGKGNVFQRV 330 LSWIPSNNHQ 340 LQLAGALAIA 350 NFARNDGNCI 360 HMVDNGIVEK 370 LMDLLDRHVE 380 DGNVTVQHAA 390 LSALRNLAIP 400 VVNKAKMLSA 410 GVTEAVLKFL 420 KSEMPPVQFK 430 LLGTLRMLID 440 AQAEAAEQLG 450 KNVKLVERLV 460 EWCEAKDHAG 470 VMGESNRLLS 480 ALIRHSKSKD 490 VIKTIVQSGG 500 IKHLVTMATS 510 EHVIMQNEAL 520 VALALIAALE 530 LGTAEKDLES 540 AKLVQILHRL 550 LADERSAPEI 560 KYNSMVLICA 570 LMGSESLHKE 580 VQDLAFLDVV 590 SKLRGHENKS 600 VAQQASLTEQ RLAVES

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005783	endoplasmic reticulum
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.