Search Results
Overview
| Uniprot ID | A0A287AH57 |
|---|---|
| Protein Name | Ubiquitin-conjugating enzyme E2 J1 |
| Gene Name | UBE2J1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 8 | METRYNLKSPAVKRL |
Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress. Plays a role in MAPKAPK2-dependent translational control of TNF synthesis. Also acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26. Plays a role in male fecundity through the interaction with the E3 ubiquitin-protein ligase RNF133
Protein Sequence
10
METRYNLKSP
20
AVKRLMKEAA
30
ELKDPTDHYH
40
AQPLEDNLFE
50
WHFTVRGPPD
60
SDFDGGVYHG
70
RIVLPPEYPM
80
KPPSIILLTA
90
NGRFEVGKKI
100
CLSISGHHPE
110
TWQPSWSIRT
120
ALLAIIGFMP
130
TKGEGAIGSL
140
DYTPEERRAL
150
AKKSQDFCCE
160
GCGFAMKDVL
170
LPLKSGSDSS
180
QADEEAKELA
190
RQISFKAEVN
200
SSGKTITESD
210
LNHSFSLHDL
220
QDDIPTTFQG
230
ATASTSYGVQ
240
NPSAASPEQP
250
AQPAAKNTSL
260
SPRQRRAQQQ
270
SQRRSSPSPD
280
VIQGQQPRDN
290
HTDHGGSAVL
300
IVILTLALAA
310
LIFRRIYLAN
EYIFDFEI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000836 | Hrd1p ubiquitin ligase complex |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0061631 | ubiquitin conjugating enzyme activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0036503 | ERAD pathway |
| Biological Process | GO:1904153 | negative regulation of retrograde protein transport, ER to cytosol |
| Biological Process | GO:0006487 | protein N-linked glycosylation |
| Biological Process | GO:0000209 | protein polyubiquitination |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.