Overview
| Uniprot ID | A0A287AHI1 |
|---|
| Protein Name | Importin subunit alpha |
|---|
| Gene Name | KPNA2 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 108 |
RKLLSREKQPPIDNI |
Function
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1
Protein Sequence
10
MSTNENANSP
20
AARLNRFKNK
30
GKDSTEMRRR
40
RIEVNVELRK
50
AKKDDQMLKR
60
RNVSSFPDDA
70
TSPLQENRNN
80
QGTVNWSVDD
90
IVKGINSNNL
100
ESQLQATQAA
110
RKLLSREKQP
120
PIDNIIRAGL
130
IPKFVSFLGR
140
MDCSPIQFES
150
AWALTNIASG
160
TSEQTKAVVD
170
GGAIPAFISL
180
LASPHAHISE
190
QAVWALGNIA
200
GDGSVFRDLV
210
IKYGAVDPLL
220
ALLAVPDMSS
230
LAVSYLTISQ
240
CGYLRNLTWT
250
LSNLCRNKNP
260
APPLDAVEQI
270
LPTLVRLLHH
280
DDPEVLADTC
290
WAISYLTDGP
300
NERIEMVVKT
310
GVVPQLVKLL
320
GATELPIVTP
330
ALRAIGNIVT
340
GTDEQTQVVI
350
DAGALAVFPS
360
LLTNSKTNIQ
370
KEATWTMSNI
380
TAGRQDQIQQ
390
VVNHGLVPFL
400
VGVLSKADFK
410
TQKEAVWAVT
420
NYTSGGTVEQ
430
IVYLVHCGII
440
EPLMNLLTAK
450
DTKIILVILD
460
AISNIFQAAE
470
KLGETEKLSI
480
MIEECGGLDK
490
IEALQNHENE
500
SVYKASLNLI
510
EKYFSVEVSS
520
NVNKNWKNTH
LRLSP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0043657 |
host cell |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0061608 |
nuclear import signal receptor activity |
| Biological Process |
GO:0075506 |
entry of viral genome into host nucleus through nuclear pore complex via importin |
| Biological Process |
GO:1903902 |
positive regulation of viral life cycle |
| Biological Process |
GO:0006606 |
protein import into nucleus |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.