Overview
| Uniprot ID | A0A287AHM1 |
|---|
| Protein Name | ATP synthase subunit gamma |
|---|
| Gene Name | ATP5F1C |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 102 |
ANLTAAGKEVKIVGV |
| 105 |
TAAGKEVKIVGVGDK |
| 112 |
KIVGVGDKIRGILHR |
| 130 |
DQFLVTFKEVGRKPP |
| 19 |
KSIKNIQKITKSMKM |
| 5 |
***MATLKDITRRLK |
| 59 |
LYEKADIKVPEDKKK |
| 66 |
KVPEDKKKHLIIGVS |
| 91 |
SSVAKQIKSEVANLT |
Function
Subunit gamma, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the central stalk subunit delta, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate
Protein Sequence
10
MATLKDITRR
20
LKSIKNIQKI
30
TKSMKMVAAA
40
KYARAERDLK
50
PARVYGIGSL
60
ALYEKADIKV
70
PEDKKKHLII
80
GVSSDRGLCG
90
AIHSSVAKQI
100
KSEVANLTAA
110
GKEVKIVGVG
120
DKIRGILHRT
130
HSDQFLVTFK
140
EVGRKPPTFG
150
DASVIALELL
160
NSGYEFDEGS
170
IIFNRFRSVI
180
SYKTEEKPIF
190
SLDTVASAES
200
MSIYDDIDAD
210
VLRNYQEYSL
220
ANIIYYSLKE
230
STTSEQSARM
240
TAMDNASKNA
250
SEMIDKLTLT
260
FNRTRQAVIT
270
KELIEIISGA
AAL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0045259 |
proton-transporting ATP synthase complex |
| Molecular Function |
GO:0046933 |
proton-transporting ATP synthase activity, rotational mechanism |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.