Search Results
Overview
| Uniprot ID | A0A287AI68 |
|---|---|
| Protein Name | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase |
| Gene Name | PAICS |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 112 | IATGSFLKRNPGVKE |
| 82 | IKTAFTRKCGETAFI |
Function
Bifunctional phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazole succinocarboxamide synthetase catalyzing two reactions of the de novo purine biosynthetic pathway
Protein Sequence
10
GAPAALRLLN
20
IGKKLYEGKT
30
KEVYELLDSP
40
GKVLLQSKDQ
50
ITAGNAARKN
60
HLEGKAAISN
70
TITSCVFQLL
80
QEAGIKTAFT
90
RKCGETAFIA
100
PKCEMIPIEW
110
VCRRIATGSF
120
LKRNPGVKEG
130
YKFYPPKVEM
140
FFKDDANNDP
150
QWSEEQLIAA
160
NFCFAGLVIG
170
QTEVDVMSHA
180
TQAIFEILEK
190
SWLPQNCTLV
200
DMKVQIQWRF
210
EKIVLADVID
220
NDSWRLWPSG
230
DRSQQKDKQS
240
YRDLKEVTPE
250
GLQMVKKNFE
260
WVAERVELLL
270
KTESQCRVVV
280
LMGSTSDLSH
290
CEKIKKACGN
300
FGIPCELRVT
310
SAHKGPDETL
320
RIKAEYEGDG
330
IPTVFVAVAG
340
RSNGLGPVMS
350
GNTAFPVISC
360
PPLSPDWGAQ
370
DVWSSLRLPS
380
GLGCSTILSP
390
EGSAQFAAQI
400
FGLNNHLVWA
410
KLRANVLNTW
420
ISLKQADKKI
REGNL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004638 | phosphoribosylaminoimidazole carboxylase activity |
| Molecular Function | GO:0004639 | phosphoribosylaminoimidazolesuccinocarboxamide synthase activity |
| Biological Process | GO:0044208 | 'de novo' AMP biosynthetic process |
| Biological Process | GO:0006189 | 'de novo' IMP biosynthetic process |
| Biological Process | GO:0097294 | 'de novo' XMP biosynthetic process |
| Biological Process | GO:0006177 | GMP biosynthetic process |
| Biological Process | GO:0009113 | purine nucleobase biosynthetic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.