Search Results
Overview
| Uniprot ID | A0A287AIP7 |
|---|---|
| Protein Name | Long-chain-fatty-acid--CoA ligase |
| Gene Name | ACSL1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 500 | IQSSLGGKVRLMVTG |
Function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation
Protein Sequence
10
MMQAHELFRY
20
FRMPELVDFQ
30
QYVRTLPTNT
40
LMGFGAFAAL
50
TTFWYATRPR
60
ALKPPCDLAM
70
QSVEVAGSDG
80
ARRSAILDSD
90
EPLAYFYDDV
100
RTLYEGFQRG
110
IRVSNNGPCL
120
GSRKPDQPYE
130
WLSYKQCPCC
140
YLGQAAAQEH
150
REPPAVFPAR
160
PSRKGLSAAG
170
PVTPWHLGTW
180
RSPCVSAAEV
190
GVSQGMCVRG
200
HLQEPQNQVE
210
DMSECVGSAL
220
IHKGFKAGPE
230
NFVGIFAQNR
240
PEWVIIEQGC
250
FAYSMVVVPL
260
YDTLGTEAIT
270
YIINKGELSL
280
VFVDKPEKAN
290
LLLEGVENKL
300
IPGLKTIILM
310
DSYGIDLLER
320
GKKCGVEIMS
330
MKALEDLGRA
340
NRRKPKPPAP
350
EDLAVICFTS
360
GTTGNPKGAM
370
ITHRNVVSDC
380
SAFVKVTEKT
390
FSPSSDDTLI
400
SFLPLAHMFE
410
RVVECVMLCH
420
GAKIGFFQGD
430
IRLLMDDLKA
440
LQPTIFPVVP
450
RLLNRMFDRI
460
FGQANTTLKR
470
WLLDFASKRK
480
EAELRSGIIR
490
NNSLWDKLIF
500
HKIQSSLGGK
510
VRLMVTGAAP
520
VSATVLTFLR
530
AALGCQFYEG
540
YGQTECTAGC
550
SLTVPGDWTA
560
GHVGAPMPCS
570
LIKLVDVEEM
580
NYLAAKGEGE
590
VCVKGPNVFQ
600
GYLKDPAKTA
610
EALDKDGWLH
620
TGDIGKWLPN
630
GTLKIIDRKK
640
HIFKLAQGEY
650
IAPEKIENIY
660
LRSEPVAQVF
670
VHGESLQAFL
680
IAIVVPDVET
690
LGHWAQKRGF
700
VGSFEELCRN
710
KDVKKAILED
720
MLRLGRDAGL
730
KSFEQVRGIS
740
LHPELFSIDN
750
GLLTPTMKAK
760
RPELRNYFRS
770
QIDELYSTVK
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Molecular Function | GO:0047676 | arachidonate-CoA ligase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0090433 | palmitoyl-CoA ligase activity |
| Molecular Function | GO:0043539 | protein serine/threonine kinase activator activity |
| Biological Process | GO:0006633 | fatty acid biosynthetic process |
| Biological Process | GO:0044539 | long-chain fatty acid import into cell |
| Biological Process | GO:0001676 | long-chain fatty acid metabolic process |
| Biological Process | GO:0035338 | long-chain fatty-acyl-CoA biosynthetic process |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:0000038 | very long-chain fatty acid metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.