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Overview

Uniprot ID	A0A287AJM8
Protein Name	Thimet oligopeptidase
Gene Name	THOP1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
163	LPKETQEKIKSIKKK
229	PHYFPLLKKCHVPET
239	HVPETRRKVEEAFNC
249	EAFNCRCKEENCAIL
406	VRDAASGKVIGKFYL

Function

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments. Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1

Protein Sequence

10 LSPPQACAGD 20 ALDVAAPCSA 30 VNYLRWDLSA 40 QQIGELTTEL 50 IEQTKRVYDR 60 VGTQELQDVS 70 YENTLKALAD 80 VEVSYTVQRN 90 ILDFPQHVSP 100 CKDIRTASTE 110 ADKKLSEFDV 120 EMSMRQDVYQ 130 RIVWLQEKVQ 140 KDSLRPEAAR 150 YLERLIKLGR 160 RNGLHLPKET 170 QEKIKSIKKK 180 LSLLCIDFNK 190 NLNEDTTFLP 200 FTREELGGLP 210 EDFLNSLEKT 220 EDEKLKVTLK 230 YPHYFPLLKK 240 CHVPETRRKV 250 EEAFNCRCKE 260 ENCAILRELV 270 RLRAQKSSLL 280 GFSTHADYVL 290 EMNMAKTSQV 300 VATFLDELAQ 310 KLKPLGEQER 320 AVILELKKAE 330 CTKRGLDFDG 340 RINAWDMRYY 350 MNQVEETRYR 360 VDQNLLKEYF 370 PMQVVTRGLL 380 GIYQELLGLT 390 FHLEEGAAVW 400 HEDVMLYSVR 410 DAASGKVIGK 420 FYLDLYPREG 430 KYGHAACFGL 440 QPGCLRQDGS 450 RQIAIAAMVA 460 NFTKPTPDAP 470 SLLQHDEVET 480 YFHEFGHVMH 490 QLCSQAEFAM 500 FSGTHVERDF 510 VEAPSQMLEN 520 WVWEAEPLLR 530 MSQHYRTGSA 540 IPQELLEKLI 550 KSRQANTGLF 560 NLRQIVLAKV 570 DQALHTQTAA 580 DPAEEYARLC 590 QEILGVPATP 600 GSHTPSQAHF 610 RGQGKRFIVM 620 YEGVWEEEFD 630 LWPFLLWFLG 640 WSLHLGAVGM 650 DYRSCILRPG 660 GSEDASVMLK 670 LFLGRDPKQD 680 AFLLSKGLQH 690 PSAASLLSAS 700 RSHSVCAESM 710 EQRSRLQYWV 720 CPAGGKASLQ 730 VALQDSSSRY LDGSYSKT

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005758	mitochondrial intermembrane space
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Biological Process	GO:0006508	proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.