Search Results
Overview
| Uniprot ID | A0A287AJU1 |
|---|---|
| Protein Name | Coactosin-like protein |
| Gene Name | COTL1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | GTDKTLVKEVVQNFA |
| 118 | EFVISDRKELEEDFI |
| 126 | ELEEDFIKSELKKAG |
| 131 | FIKSELKKAGGANYD |
| 7 | *MATKIDKEACRTAY |
| 72 | TTGDAMSKRSKFALI |
| 98 | RAKTGTDKTLVKEVV |
Function
Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis
Protein Sequence
10
MATKIDKEAC
20
RTAYNLVRDD
30
SSAVIWVTFK
40
YDGSTIVPGE
50
QGAEYQDFIQ
60
QCTDDVRLFA
70
FVRFTTGDAM
80
SKRSKFALIT
90
WIGENVSGLQ
100
RAKTGTDKTL
110
VKEVVQNFAK
120
EFVISDRKEL
130
EEDFIKSELK
140
KAGGANYDAQ
TE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030427 | site of polarized growth |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Biological Process | GO:0050832 | defense response to fungus |
| Biological Process | GO:0030833 | regulation of actin filament polymerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.