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Overview

Uniprot IDA0A287AK18
Protein NameMatrin-3
Gene NameMATR3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
3 *****MSKSFQQSSL
477 PDQKFDQKQELGRVI
508 KLAEPYGKIKNYILM
541 MVDHCLKKALWFQGR
551 WFQGRCVKVDLSEKY
557 VKVDLSEKYKKLVLR
603 SKTDGSQKTESTTEG
611 TESTTEGKEQEEKSG
688 PSDKAVKKDANASAS
699 ASASAASKKKLKKVD
707 KKLKKVDKIEELDQE
805 YTNEEVAKNTHCSSL
817 SSLPHYQKLKKFLNK
824 KLKKFLNKLAEERRQ

Function

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. May bind to specific miRNA hairpins

Protein Sequence

10 MSKSFQQSSL 20 GRDSQGHGRD 30 LSAAGIGLLA 40 AATQSLSMPA 50 SLGRMNQGTA 60 RLASLMNLGM 70 SSSLNQQGAH 80 SALSSASTSS 90 HNLQSIFNIG 100 SRGPLPLSSQ 110 HRGDADQASN 120 ILASFGLSAR 130 DLDELSRYPE 140 DKITPENLPQ 150 ILLQLKRRRT 160 EEGPTLSYGR 170 DGRSATREPP 180 YRVPRDDWEE 190 KRHFRRDSFD 200 DRGPSLNPVL 210 DYDHGSRSQE 220 SGYYDRMDYE 230 DDRLRDGERC 240 RDDSFFGETS 250 HNYHKFDSEY 260 ERMGRGPGPL 270 QERSLFEKKR 280 GAPPSSNIED 290 FHGLLPKGYP 300 HLCSICDLPV 310 HSNKEWSQHI 320 NGASHSRRCQ 330 LLLEMGDPFM 340 LQQSTNPAPG 350 ILGPPPPSFH 360 LGGPAVGPRG 370 NLGAGNGNLQ 380 GPRHMQKGRV 390 ETSRVVHIMD 400 FQRGKNLRYQ 410 LLQLVEPFGV 420 ISNHLILNKI 430 NEAFIEMATT 440 EDAQAAVDYY 450 TTTPALVFGK 460 PVRVHLSQKY 470 KRIKKPEGKP 480 DQKFDQKQEL 490 GRVIHLSNLP 500 HSGYSDSAVL 510 KLAEPYGKIK 520 NYILMRMKSQ 530 AFIEMETRED 540 AMAMVDHCLK 550 KALWFQGRCV 560 KVDLSEKYKK 570 LVLRIPNRGI 580 DLLKKDKSRK 590 RSYSPDGKES 600 PSDKKSKTDG 610 SQKTESTTEG 620 KEQEEKSGED 630 GEKDTKDDQA 640 EQEPSMLLES 650 EDELLVDEEE 660 AAALLESGSS 670 VGDETDLANL 680 GDVASDGKKE 690 PSDKAVKKDA 700 NASASAASKK 710 KLKKVDKIEE 720 LDQENEAALE 730 NGIKNEENTE 740 PGAESAENAD 750 DPNKDTSENA 760 DGQSDENKED 770 YTIPDEYRIG 780 PYQPNVPVGI 790 DYVIPKTGFY 800 CKLCSLFYTN 810 EEVAKNTHCS 820 SLPHYQKLKK 830 FLNKLAEERR QKKEA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016363 nuclear matrix
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0045087 innate immune response

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.