Search Results
Overview
| Uniprot ID | A0A287AK42 |
|---|---|
| Protein Name | Phosducin-like protein 3 |
| Gene Name | PDCL3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 91 | KATQMKNKFGEVLEI |
Function
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis
Protein Sequence
10
MQDPNADTEW
20
NDILRKKGIL
30
PSKESLTELE
40
KEAEEEEQQA
50
LQQSIVKTYE
60
DMTLEELEDN
70
EDEFNEEDER
80
AIEMYRQQRL
90
AEWKATQMKN
100
KFGEVLEISG
110
KDYVQEVTKA
120
GEGLWVILHL
130
YKQGIPLCAL
140
INQHFSGLAR
150
KFPDVKFIKA
160
ISTTCIPNYP
170
DRNLPTIFVY
180
LEGDIKAQFI
190
GPLVFGGMNL
200
TMDELEWKLS
210
ESGAIKTSLE
220
ENPKKPIEDM
230
LLSSVRGSGP
240
ARRDSDSDDD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0097356 | perinucleolar compartment |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0043184 | vascular endothelial growth factor receptor 2 binding |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0001525 | angiogenesis |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:1903333 | negative regulation of protein folding |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.