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Overview

Uniprot IDA0A287AKE0
Protein NameNardilysin
Gene NameNRDC
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
742 PGAHHLCKVRALNKG

Function

Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH)

Protein Sequence

10 MILAWAGQSP 20 FAFLSVSAFS 30 LRSVPVQHLA 40 GWREEEQQGE 50 TDTVLSAAAL 60 CVGVGSFADP 70 DDLPGLAHFL 80 EHMVFMGSLK 90 YPDENGFDAF 100 LKKHGGSDNA 110 STDCERTVFQ 120 FDVQRKYFKE 130 ALDRWAQFFI 140 HPLMIRDAID 150 REVEAVDSEY 160 QLARPSDANR 170 KEMLFGSLAR 180 PGHPMGKFFW 190 GNAETLKHEP 200 KRNNIDTHAR 210 LREFWMRFYS 220 AHYMTLVVQS 230 KETLDTLEKW 240 VTEIFSQIPN 250 NGLPKPNFGH 260 LTDPFDTPAF 270 NKLYRVVPIR 280 KIHALTITWA 290 LPPQQQHYRS 300 KPLHYISWLV 310 GHEGKGSILS 320 YLRKKCWALA 330 LFGGNGETGF 340 EQNSTYSVFS 350 ISITLTDEGY 360 EHFYEVAHTV 370 FQYLKMLQKL 380 GPEKRIFEEI 390 QKIEDNEFHY 400 QEQTDPVEYV 410 ENMCENMQLY 420 PLQDFLTGDQ 430 LLFEYKPEVI 440 AEALNQLVPQ 450 KANLVLLSGA 460 NEGKCDLKEK 470 WFGTQYSMED 480 IENSWAELWK 490 SNFELNPDLH 500 LPAENKYIAT 510 DFMLKAFDCP 520 ETEYPVKIVN 530 TPQGCLWYKK 540 DNKFKIPKAY 550 IRFHLISPLI 560 QKSAANVVLF 570 DIFVNILTHN 580 LAEPAYEADV 590 AQLEYKLVAG 600 EHGLIIRVKG 610 FNHKLPLLFQ 620 LIIDYLAEFT 630 STPAVFTMIT 640 EQLKKTYFNI 650 LIKPETLAKD 660 VRLLILEYAR 670 WSMIDKYRAL 680 MDGLSLESLL 690 SFVKEFKAQL 700 FVEGLVQGNV 710 TSTESTDFLK 720 YVVDKLNFMP 730 LEQEMPVQFR 740 VVELPGAHHL 750 CKVRALNKGD 760 ANSEVTVYYQ 770 SGARSLKEYT 780 LMELLVMHME 790 EPCFDFLRTK 800 QTLGYHVYPT 810 CRNTSGILGF 820 SVTVGTQATK 830 YNSEVVDKKI 840 EEFLSSFEEK 850 IENLTEDAFN 860 TQVTALIKLK 870 ECEDTHLGEE 880 VDRNWNEVVT 890 QQYLFDRLAH 900 EIEALKSFSK 910 SDLVSWFKAH 920 RGPGSKMLSV 930 HVVGFGKHEL 940 EEDGIPSSED 950 SNSSCEVMQL 960 TYLPASPLLA 970 DSTIPITDIR 980 AFTSTLNLLP YHKIVK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030425 dendrite
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004222 metalloendopeptidase activity
Biological Process GO:0006508 proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.