Search Results
Overview
| Uniprot ID | A0A287AKR8 |
|---|---|
| Protein Name | L antigen family member 3 |
| Gene Name | LAGE3 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 66 | GDPASAAKRPRSRAH |
Function
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex
Protein Sequence
10
MQAADAAAGA
20
SGAAGGSEGP
30
GRRGAPGGRG
40
RPRGAGAAAV
50
AAAGVPPVAP
60
AQRTSEEGGD
70
PASAAKRPRS
80
RAHVFALSVP
90
FPSSWEAEIA
100
RGSLAPDAEP
110
HRGAVGKELT
120
VSGSDLAVHW
130
RADDSRLLRI
140
SIVNFLDQLS
150
LVIRTMQRFG
PPVSR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0000408 | EKC/KEOPS complex |
| Cellular Component | GO:0005634 | nucleus |
| Biological Process | GO:0008033 | tRNA processing |
| Biological Process | GO:0070525 | tRNA threonylcarbamoyladenosine metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.