Overview
| Uniprot ID | A0A287AL05 |
|---|
| Protein Name | Eukaryotic translation initiation factor 3 subunit L |
|---|
| Gene Name | EIF3L |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 272 |
YRCKTAKKSEEEIDF |
| 366 |
LENIELNKKSMYSRV |
| 559 |
RIQLLVFKHKMKNLV |
| 614 |
FFIRQIHKFEELNRT |
Function
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression
Protein Sequence
10
MPWERPKKRQ
20
KDKTKQNERN
30
RPVAIESDIK
40
RIYISGCLKG
50
NGSSLVAQRV
60
KDLMPLLWLW
70
SLDCCGNFCM
80
PPPLPTKGII
90
PNCIDFSLGG
100
GRPCPFVTHV
110
DLRCHIPPLG
120
DPKQDLAYER
130
QYEQQTYQVI
140
PEVIKNFIQY
150
FHKTVSDLID
160
QKVYEIQDIY
170
ENSWTKLTER
180
FFKNTPWPEA
190
ETIAPQVGND
200
AVFLILYKEL
210
YYRHIYAKVS
220
GGPSLEQRFE
230
SYYNYCNLFN
240
YILNADGPAP
250
LELPNQWLWD
260
IIDEFIYQFQ
270
SFSQYRCKTA
280
KKSEEEIDFL
290
RSNPKIWNVH
300
SVLNVLHSLV
310
DKSNINRQLE
320
VYTSGGDPES
330
VAGEYGRHSL
340
YKMLGYFSLV
350
GLLRLHSLLG
360
DYYQAIKVLE
370
NIELNKKSMY
380
SRVPECQVTT
390
YYYVGFAYLM
400
MRRYQDAIRV
410
FANILLYIQR
420
TKSMFQRTTY
430
KYEMINKQNE
440
QMHALLAIAL
450
TMYPMRIDES
460
IHLQLREKYG
470
DKMLRMQKGD
480
PQVYEELFSY
490
SCPKFLSPVV
500
PNYDNVHPNY
510
HKEPFLQQLK
520
VFSDEVQQQA
530
QLSTIRSFLK
540
LYTTMPVAKL
550
AGFLDLTEQE
560
FRIQLLVFKH
570
KMKNLVWTSG
580
ISALDGEFQS
590
ASEVDFYIDK
600
DMIHIADTKV
610
ARRYGDFFIR
620
QIHKFEELNR
TLKKMGQRP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016282 |
eukaryotic 43S preinitiation complex |
| Cellular Component |
GO:0033290 |
eukaryotic 48S preinitiation complex |
| Cellular Component |
GO:0005852 |
eukaryotic translation initiation factor 3 complex |
| Cellular Component |
GO:0001650 |
fibrillar center |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0003743 |
translation initiation factor activity |
| Biological Process |
GO:0001732 |
formation of cytoplasmic translation initiation complex |
| Biological Process |
GO:0006413 |
translational initiation |
| Biological Process |
GO:0075525 |
viral translational termination-reinitiation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.