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Overview

Uniprot ID	A0A287AL47
Protein Name	CAAX prenyl protease
Gene Name	ZMPSTE24
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
208	VYVVEGSKRSSHSNA

Function

Proteolytically removes the C-terminal three residues of farnesylated proteins

Protein Sequence

10 MGMWASLDAM 20 WEMPAEKRIF 30 GAVLLFSWTV 40 YLWETFLAQR 50 QRRIYKTTTH 60 VPLELGQIMD 70 SETFEKSRLY 80 QLDKSTFSFW 90 SGLYSEIEGT 100 LILLFGGIPY 110 LWRLSGRFCG 120 YAGFGPEYEI 130 TQSLVFLLLA 140 TLFSALTGLP 150 WSLYNTFVIE 160 EKHGFNQQVL 170 VTIYADYIAP 180 LFDKFTPLPE 190 GKLKQEIEIM 200 AKSIDFPLTK 210 VYVVEGSKRS 220 SHSNAYFYGF 230 FKNKRIVLFD 240 TLLEEYSVLN 250 KDIQEESGME 260 PRNDGEGDSE 270 EIKAKVKNKK 280 QGCKNEEVLA 290 VLGHELGHWK 300 LGHTVKNIVI 310 SQVNSFLCFF 320 LFAVLIGRKE 330 LFVAFGFYDS 340 QPTLIGLLII 350 FQFIFSPYNE 360 VLSFCLTVLS 370 RRFEFQADAF 380 AKKLGKAKDL 390 YSALIKLNKD 400 NLGFPVSDWL 410 FSMWHYSHPP 420 LLERLQALKN SKQD

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0004222	metalloendopeptidase activity
Biological Process	GO:0071586	CAAX-box protein processing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.