Search Results
Overview
| Uniprot ID | A0A287AL53 |
|---|---|
| Protein Name | Palmitoyl-protein thioesterase ABHD10, mitochondrial |
| Gene Name | ABHD10 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 129 | LKECTVGKWRKDVLS |
Function
Acts as an acyl-protein thioesterase that hydrolyzes fatty acids from acylated residues in proteins. Regulates the mitochondrial S-depalmitoylation of the nucleophilic active site residue of peroxiredoxin-5/PRDX5, a key antioxidant protein, therefore modulating mitochondrial antioxidant ability. Also catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, an active metabolite of the immunosuppressant drug mycophenolate
Protein Sequence
10
MAGVGLAAAA
20
SWVPCRRRGW
30
AVVSFGFHRG
40
LSALLARKPE
50
RAPWWLAACR
60
QKTSVSFLSR
70
PDLPNLAYKK
80
LKGKSPGIIF
90
IPGYISTMNG
100
TKALAIEDFC
110
KSLGHAYIRF
120
DYSGIGNSDG
130
NLKECTVGKW
140
RKDVLSVIDE
150
LAEGPQILVG
160
SSLGGWLMLH
170
AAIARPQKVV
180
ALVGIATAVD
190
GLVTQFNQLP
200
VETKKDIEMK
210
GVWAMPSKYS
220
EEGVYRIQYS
230
VIKEAEHHCL
240
LHSPIPVNCP
250
IRLLHGMKDD
260
VIPWHTSVQV
270
ADRVVSKDVD
280
VILRKDSDHR
290
MKEKADLQLL
300
VYTIDDLIDK
LSTVIN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds |
| Molecular Function | GO:0102390 | mycophenolic acid acyl-glucuronide esterase activity |
| Molecular Function | GO:0008474 | palmitoyl-(protein) hydrolase activity |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.