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Overview

Uniprot ID	A0A287AL55
Protein Name	Alpha-1,4 glucan phosphorylase
Gene Name	PYGB
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
511	VKQENKVKFSAFLEK
777	RNIACSGKFSSDRTI

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

Protein Sequence

10 MAKPLTDGER 20 RKQISVRGLA 30 GLGDVAEVRK 40 SFNRHLHFTL 50 VKDRNVATRR 60 DYYLALAHTV 70 RDHLVGRWIR 80 TQQHYYERDP 90 KLGLDLEELE 100 EMEEDAGLGN 110 GGLGRLAACF 120 LDSMATLGLA 130 AYGYGIRYEF 140 GIFNQKIVNG 150 WQVEEADDWL 160 RYGNPWEKAR 170 PEYTLPVHFY 180 GRVEHSAEGV 190 RWLDTQVVLA 200 MPYDTPVPGY 210 KNDTVNTMRL 220 WSAKAPNDFK 230 LHDFNVGGYI 240 EAVLDRNLAE 250 NISRVLYPND 260 NFFEGKELRL 270 KQEYFVVAAT 280 LQDVIRRFKS 290 AKFGCRDPVR 300 TSFDTFPDKV 310 AIQLNDTHPA 320 LAIPELMRIL 330 VDVEKVDWDK 340 AWDITKKTCA 350 YTNHTVLPEA 360 LERWPVSMFE 370 KLLPRHLEII 380 YAINQRHLDH 390 VAALFPGDVD 400 RLRRMSVIEE 410 GDCKRINMAH 420 LCVIGSHAVN 430 GVARIHSEIV 440 KHSVFKDFYE 450 LEPEKFQNKT 460 NGITPRRWLL 470 LCNPGLADTI 480 MERIGEGFLT 490 DLSQLRKLLP 500 LVNDEALIRD 510 VAQVKQENKV 520 KFSAFLEKEY 530 GVKVNPASMF 540 DVHVKRIHEY 550 KRQLLNCLHV 560 VTLYNRIKKD 570 PGQAFVPRTV 580 MIGGKAAPGY 590 HMAKMIIKLV 600 TSIGDIVNHD 610 PVVGGRLKVI 620 FLENYRVSLA 630 EKVIPAADLS 640 QQISTAGTEA 650 SGTGNMKFML 660 NGALTIGTMD 670 GANVEMAEEA 680 GAENLFIFGL 690 RVEDVEALDR 700 KGYNAREYYE 710 RLPELRQAVD 720 QISNGFFSPR 730 KPDCFKDLVD 740 MLLNHDRFKV 750 FADYEAYVAC 760 QARVDQLYQD 770 PKEWTKKVIR 780 NIACSGKFSS 790 DRTITEYARD 800 IWGVEPSAQQ AQAPSLPRD

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0008184	glycogen phosphorylase activity
Molecular Function	GO:0030170	pyridoxal phosphate binding
Biological Process	GO:0005977	glycogen metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.