Search Results

Overview

Uniprot IDA0A287AL94
Protein NameAlpha-1,4 glucan phosphorylase
Gene NamePYGL
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
29 VENVAELKKGFNRHL
42 HLHFTLVKDRNVATP
421 KIAALFPKDVDRLRR
465 KIHSDIVKTQVFKDF
539 LREISNVKQENKLKF
545 VKQENKLKFSQFLEK
724 EDVAALDKKGYNAKE
78 TQQYYYEKCPKRVYY

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

Protein Sequence

10 MAKPLTDQEK 20 RRQISIRGIV 30 GVENVAELKK 40 GFNRHLHFTL 50 VKDRNVATPR 60 DYFFALAHTV 70 RDHLVGRWIR 80 TQQYYYEKCP 90 KRVYYLSLEF 100 YIGRTLQNTM 110 INLGLQNACD 120 EAIYQLGLDM 130 EELEEIEEDA 140 GLGNGGLGRL 150 AACFLDSMAT 160 LGLAAYGYGI 170 RYEYGIFNQK 180 IRDGWQIEEA 190 DDWLRHGNPW 200 EKARPEFMLP 210 VHFYGRVEHT 220 EAGTKWVDTQ 230 VVLALPYDTP 240 VPGYLNNTVN 250 TMRLWSARAP 260 NDFNLRDFNV 270 GDYIQAVLDR 280 NLAENISRVL 290 YPNDNFFEGK 300 ELRLKQEYFV 310 VAATLQDVIR 320 RFKASKFGSS 330 DSAGTAFDAF 340 PDQVAIQLND 350 THPALAIPEL 360 MRIFVDIEKL 370 PWSKAWGITQ 380 KTFAYTNHTV 390 LPEALERWPV 400 ELVEKLLPRH 410 LQIIYEINQK 420 HLDKIAALFP 430 KDVDRLRRMS 440 LIEEEGGKRI 450 NMAHLCIVGS 460 HAVNGVAKIH 470 SDIVKTQVFK 480 DFSELEPDKF 490 QNKTNGITPR 500 RWLLLCNPGL 510 AELIAEKIGE 520 DYVKDLSQLT 530 KLHHFLGDDV 540 FLREISNVKQ 550 ENKLKFSQFL 560 EKEYKVKINP 570 ASMFDVQVKR 580 IHEYKRQLMN 590 CLHVITMYNR 600 IKKDPKKLFV 610 PRTVIIGGKA 620 APGYHMAKLI 630 IKLITSVAEV 640 VNNDPVVGSK 650 LKVIFLENYR 660 VSLAEKVIPA 670 TDLSEQISTA 680 GTEASGTGNM 690 KFMLNGALTI 700 GTMDGANVEM 710 AEEAGEENLF 720 IFGMRVEDVA 730 ALDKKGYNAK 740 EYYEALPELK 750 LAIDQIDKGF 760 FSPKQPDLFK 770 DLVNMLFHHD 780 RFKVFADYEA 790 YVKCQEKVSQ 800 LYMNPKAWNT 810 MVLKNIAAAG 820 KFSSDRTIKE 830 YARDIWNMEP 840 SDLKISLSSE 850 PSGGVHKANG KLDK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Molecular Function GO:0016208 AMP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0032052 bile acid binding
Molecular Function GO:0005536 D-glucose binding
Molecular Function GO:0008184 glycogen phosphorylase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0002060 purine nucleobase binding
Molecular Function GO:0030170 pyridoxal phosphate binding
Biological Process GO:0042593 glucose homeostasis
Biological Process GO:0005980 glycogen catabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.