Overview
| Uniprot ID | A0A287ALS6 |
|---|
| Protein Name | Single-stranded DNA-binding protein, mitochondrial |
|---|
| Gene Name | SSBP1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 103 |
DVAYQYVKKGSRVYV |
Function
Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair
Protein Sequence
10
MFRRPVFQVL
20
HQFVRHESEV
30
ASSLVLERSL
40
NRVQLLGRVG
50
QDPVMRQVEG
60
KNPVTIFSLA
70
TNEMWRSGEN
80
EAYQMGDVSQ
90
KTTWHRISVF
100
RPGLRDVAYQ
110
YVKKGSRVYV
120
EGKVDYGEYT
130
DKNNVRRQAT
140
TIIAGLYPWH
150
MEVRTYICQP
160
TSIAHDNTGS
LIH
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0042645 |
mitochondrial nucleoid |
| Molecular Function |
GO:0003682 |
chromatin binding |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Molecular Function |
GO:0003697 |
single-stranded DNA binding |
| Biological Process |
GO:0006264 |
mitochondrial DNA replication |
| Biological Process |
GO:0090297 |
positive regulation of mitochondrial DNA replication |
| Biological Process |
GO:0051289 |
protein homotetramerization |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.