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Overview

Uniprot IDA0A287ALX0
Protein NameEndoplasmic reticulum disulfide reductase DNAJC10
Gene NameDNAJC10
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
710 IRAYPTVKFYPYEGT

Function

Endoplasmic reticulum disulfide reductase that collaborates directly with the chaperone BIP/HSPA5 (GRP78) to maintain protein quality control by facilitating either the correct folding or the targeted degradation of misfolded proteins. Essential for efficient maturation of newly synthesized polypeptides in the endoplasmic reticulum, binds to substrate proteins and specifically catalyzes the reduction and removal of improper (non-native) disulfide bonds during the folding process. In endoplasmic reticulum-associated degradation (ERAD), DNAJC10 reduces incorrect disulfide bonds specifically in misfolded glycoproteins that have been recognized by EDEM1, a key component of the ERAD pathway, thereby enabling their retrotranslocation and degradation. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress

Protein Sequence

10 MGVWLNKDAY 20 IRDLKRVILC 30 FLLVYMAILV 40 GTDQDFYSLL 50 GVSKTASSRE 60 IRQAFKKLAL 70 KLHPDKNPNN 80 PNAHSDFLKI 90 NKAYEVLKDE 100 DLRKKYDKYG 110 EKGLADNQGG 120 GQYESWNYYR 130 YDFGIYDDDP 140 EIITLDRSEF 150 DAAVNSGELW 160 FVNFYSSGCS 170 HCHDLAPTWR 180 DFAREVDGLL 190 RIGAVNCGDD 200 RMLCRMKGVS 210 SYPSLFIFRS 220 GMAAVKYHGD 230 RSKESLVNFA 240 MQYVRSTVTE 250 LWTGNFVNSI 260 QTAFAAGIGW 270 LITFCSKGGD 280 CLTSQTRLRL 290 SGMLDGLVNV 300 GWMDCATQDN 310 LCKSLDITTS 320 TTAYFPPGAT 330 LNNKEKSSIL 340 FLNSLDAKEI 350 YLEIMHNLPD 360 FELLSANTLE 370 VGKFDCSSAP 380 DICSNLYVFQ 390 PCLAVFKGQG 400 TKEFEIHHGK 410 KILYDILAFA 420 KESVNSHVTT 430 LGPQNFPTSD 440 KEPWLVDFFA 450 PWCPPCRALL 460 PELRKASKHL 470 YGQLKFGTLD 480 CTVHEGLCNM 490 YNIQAYPTTV 500 VFNQSNIHEY 510 EGHHSAEQIL 520 EFVEDLMNPS 530 VVSLTPTTFD 540 ELVRQRKPDE 550 VWMVDFYSPW 560 CHPCQVLMPE 570 WKRMARTLTG 580 LINVGSIDCQ 590 QYHSLCAQEN 600 VRRYPEIRFF 610 PQKSNKAYQY 620 HSYNGWNRDA 630 YSLRIWGLGF 640 LPQASIDLTP 650 QTFNEKVLQG 660 KSHWVVDFYA 670 PWCGPCQNFA 680 PEFELLARMV 690 KEKVKAGKVD 700 CQAYAQTCQK 710 AGIRAYPTVK 720 FYPYEGTRRN 730 IWGEQIDSRD 740 AKEITTLIYE 750 KLENLQNHGK 760 RNKVRNLEFT LTNII

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005788 endoplasmic reticulum lumen
Molecular Function GO:0051117 ATPase binding
Molecular Function GO:0015035 protein-disulfide reductase activity
Molecular Function GO:0051087 protein-folding chaperone binding
Biological Process GO:0036503 ERAD pathway
Biological Process GO:0034975 protein folding in endoplasmic reticulum

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.