Search Results
Overview
| Uniprot ID | A0A287AM09 |
|---|---|
| Protein Name | C-terminal-binding protein 1 |
| Gene Name | CTBP1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 280 | KALAQALKEGRIRGA |
| 348 | GRIPDSLKNCVNKDH |
| 88 | LTREDLEKFKALRII |
Function
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation
Protein Sequence
10
MGSSHLLNKG
20
LPLGVRPPIM
30
NGPMHPRPLV
40
ALLDGRDCTV
50
EMPILKDVAT
60
VAFCDAQSTQ
70
EIHEKVLNEA
80
VGALMYHTIT
90
LTREDLEKFK
100
ALRIIVRIGS
110
GFDNIDIKSA
120
GDLGIAVCNV
130
PAASVEETAD
140
STMCHILNLY
150
RRTTWLHQAL
160
REGTRVQSVE
170
QIREVASGAA
180
RIRGETLGII
190
GLGRVGQAVA
200
LRAKAFGFNV
210
LFYDPYLADG
220
TERALGLQRV
230
STLQDLLFHS
240
DCVTLHCGLN
250
EHNHHLINDF
260
TVKQMRQGAF
270
LVNTARGGLV
280
DEKALAQALK
290
EGRIRGAALD
300
VHESEPFSFS
310
QGPLKDAPNL
320
ICTPHAAWYS
330
EQASIEMREE
340
AAREIRRAIT
350
GRIPDSLKNC
360
VNKDHLAAAT
370
HWASVDPAVV
380
HPELNGAAYR
390
YPGVVGVAPS
400
GIPAAVEGIV
410
PSAMSLSHGL
420
PPVSHPPHAP
430
SPGQTVKPEA
DRDHASDQL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051287 | NAD binding |
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0001221 | transcription coregulator binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0001222 | transcription corepressor binding |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.