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Overview

Uniprot ID	A0A287AM26
Protein Name	Aminopeptidase B
Gene Name	RNPEP
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
160	PEQTAGKKKPFVYTQ
161	EQTAGKKKPFVYTQG
468	FPELKRRKVDSIPGL
588	DHQEDFWKVKEFLCS
590	QEDFWKVKEFLCSQG
598	EFLCSQGKQKYTLPL

Function

Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)-somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4)

Protein Sequence

10 MAGSGPGAGR 20 RVLRSAQAED 30 VASASNFRAF 40 ELLHLHLDLR 50 AEFGPPGPGP 60 GSRGLSGSAV 70 LELRCLEPGG 80 AAELRLDSHP 90 CLEVTAAVLR 100 RGQPGPGQPE 110 PEPEPVPVCT 120 QPFSHYGQAL 130 CVRFPQPCSA 140 GEHMQVQLTY 150 RVGEGPGVCW 160 LTPEQTAGKK 170 KPFVYTQGQA 180 VLNRAFFPCF 190 DTPAVKCRYS 200 ALIEVPDGFT 210 AVMSADTWEK 220 RGPRKFFFQM 230 SQPIPSYLIA 240 LAIGDLVSAE 250 VGPRSRVWAE 260 PCLIDAAKEE 270 YDGVIEEFLA 280 TGEKLFGPYV 290 WGRYDVLFMP 300 PSFPFGGMEN 310 PCLTFVTPCL 320 LAGDRSLADV 330 IIHEISHSWF 340 GNLVTNAHWG 350 EFWLNEGFTM 360 FAQRRISTIL 370 FGAAYTCLEA 380 ATGRALLRQH 390 MDVTGEEHPL 400 NKLRVKIEPG 410 VDPDDTYNET 420 PYEKGFCFVS 430 YLAHLVGDQD 440 QFDRFLRAYV 450 EEFKFQSILA 460 DDFLEFFLDY 470 FPELKRRKVD 480 SIPGLEFDRW 490 LNTPGWPPFL 500 PDLSPGDALM 510 KPADELAELW 520 ATEALDMRAI 530 GAVSTSAWKT 540 YQLVYFLDRI 550 LQKSPLPPGN 560 VKKLGETYPK 570 ISNAQNAELR 580 LRWGQIVLKN 590 DHQEDFWKVK 600 EFLCSQGKQK 610 YTLPLYHAMM 620 GGSEAARALA 630 KETFAATASQ 640 LHSNVVHYVQ QIVEPLGS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005615	extracellular space
Molecular Function	GO:0070006	metalloaminopeptidase activity
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006508	proteolysis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.