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Overview

Uniprot IDA0A287AM59
Protein NameBeta-hexosaminidase
Gene NameHEXA
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
398 EVFDNKVKVRPDTII

Function

Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A

Protein Sequence

10 MASRDSASWE 20 RRDRRSMAAS 30 TLWFSLLLAA 40 ASAGRATALW 50 PWPQYIKTSD 60 WSYTIVPHTF 70 QFQYHKSSAA 80 QVGCSVLDEA 90 FQRYRDLLFG 100 SVTLHFRHRV 110 EKWHISEKNS 120 LVVLVVTPGC 130 DQLPSLESVE 140 NYTLTINDEQ 150 CFLLSETVWG 160 ALRGLETFSQ 170 LIWKSPEGTF 180 YINRTEIEDF 190 PRFPHRGLLL 200 DTSRHYLPLA 210 SILDTLDVMA 220 YNKFNVFHWH 230 LVDDSSFPYE 240 SFTFPDLTKK 250 GSYNPSTHIY 260 TARDVKEVIE 270 YARLRGIRVL 280 AEFDTPGHTQ 290 SWGPGVPGLL 300 TPCYSGSQPS 310 GTFGPVNPTL 320 NYTYEFMSTF 330 FSEISSVFPD 340 FYLHLGGDEV 350 DFTCWKSNPD 360 IQNFMKQKGF 370 GKDFKKLESF 380 YIQTLLGIVS 390 GYGKGYVVWQ 400 EVFDNKVKVR 410 PDTIIQVWRE 420 EIPVKYMKEM 430 ELVTLAGFRA 440 LLSAPWYLNH 450 ITYGPDWKEV 460 YMVEPLAFEG 470 TPEQKALVIG 480 GEACMWGEYV 490 DSTNLVPRLW 500 CVGWRLLSPL HR

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005764 lysosome
Molecular Function GO:0004563 beta-N-acetylhexosaminidase activity
Biological Process GO:1901135 carbohydrate derivative metabolic process
Biological Process GO:0005975 carbohydrate metabolic process
Biological Process GO:0006629 lipid metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.