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Overview

Uniprot ID	A0A287AM95
Protein Name	Elongation factor G, mitochondrial
Gene Name	GFM1
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
401	RNYQGELKKGDTIYN
542	GCPCITGKPKVAFRE

Function

Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis

Protein Sequence

10 MRLLGAAAAA 20 AAVGRGPLPR 30 IPAALGWPGK 40 QANWKICRWC 50 SSGVIPNEKI 60 RNIGISAHID 70 SGKTTLTERV 80 LYYTGRIAKM 90 HEVKGKDGVG 100 AVMDSMELER 110 QRGITIQSAA 120 TYTLWKDVNI 130 NIIDTPGHVD 140 FTIEVERALR 150 VLDGAILVLC 160 AVGGVQCQTM 170 TVNRQMQRYS 180 VPFLTFINKL 190 DRMGSNPTRA 200 LQQMRSKLNH 210 NAALVQIPIG 220 LEGDFKGIID 230 LIEERAIYFD 240 GDFGSFLRDF 250 RSLLWNWDCW 260 SSSQIVRYGE 270 IPAEFRAAAS 280 DHRQELIESV 290 ANSDEQLGEM 300 FLEEKIPSAS 310 DLKLAIRRAT 320 INRSFTPVFL 330 GSALKNKGVQ 340 PLLDAVVEYL 350 PNPSEVQNYA 360 ILNQDDSQEK 370 TKILMNSKRD 380 DSHPFVGLAF 390 KLEAGRFGQL 400 TYVRNYQGEL 410 KKGDTIYNTR 420 TRKKVRVQRL 430 VRMHADMMED 440 VEEVFAGDIC 450 ALFGIDCASG 460 DTFTNKENSG 470 LSMESIHVPD 480 PVISIAMKPS 490 NKNDLEKFSK 500 GIGRFTREDP 510 TFKVHFDTES 520 KETIVSGMGE 530 LHLEIYAQRM 540 EREYGCPCIT 550 GKPKVAFRET 560 ITAPVPFEFT 570 HKKQSGGAGQ 580 FGKVIGVLEP 590 LDPENYTKLE 600 FSDETFGANV 610 PKQFVPAVEK 620 GFLDACEKGP 630 LSGHKLSGLR 640 FVLQDGAHHM 650 VDSNEISFIR 660 AGEGALKQAL 670 ANATVCILEP 680 IMSVEVIAPN 690 EFQGPVIAGI 700 NRRHGVITGQ 710 DGVEDYFTVY 720 AEVPLNDMFG 730 YSTELRSCTE 740 GKGEYTMEYC 750 RYQPCSPATQ 760 EDLVNKYLEA 770 TGQLPVKKGK AKN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Molecular Function	GO:0003746	translation elongation factor activity
Biological Process	GO:0070125	mitochondrial translational elongation

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.