Search Results

Overview

Uniprot ID	A0A287AME7
Protein Name	Medium-chain acyl-CoA ligase ACSF2, mitochondrial
Gene Name	ACSF2
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
106	RLTFAQLKEQVDKAA
179	CKALVFPKQFKTQQY
199	QICPEVEKAKPGALK
250	AQLRHTQKFLSCHDP
296	ERLQLSQKTAEKSRM
487	DEVIGQDKWYRTGDI
570	KTTAEEIKAFCKGKI

Function

Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation

Protein Sequence

10 MAVYLGMLRV 20 VRLCAGRPEV 30 LGARGGLSRV 40 WQEARLWGVR 50 PLSSGEVDHT 60 APLPIGGLSY 70 IQGNTKLRLI 80 NKTVGWCLDA 90 TAQKIPDKEA 100 LVVFHENIRL 110 TFAQLKEQVD 120 KAAAGLLSIG 130 LRKGDRLGMW 140 GPNSYAWVLI 150 QLATAQAGII 160 LVSVNPAYQA 170 PELEYALKKV 180 GCKALVFPKQ 190 FKTQQYYNIL 200 KQICPEVEKA 210 KPGALKSQRL 220 PDLTIVISVD 230 TPLPGTLLLD 240 DVVAAGNQEQ 250 HLAQLRHTQK 260 FLSCHDPINI 270 QFTSGTTGSP 280 KGATLSHYNI 290 VNNSNMIGER 300 LQLSQKTAEK 310 SRMVLPTPLY 320 HCLGSVGGTM 330 VSLMHGVTLI 340 LSSPVFDGKK 350 ALEAISRERG 360 SFLYGTPTMF 370 VDILNQPDFS 380 SYDISAICGG 390 VIAGSPVPPE 400 LIRAIINKMN 410 MKELVVAYGT 420 TENSPVTFMN 430 FPEDTMEQKA 440 ESVGRVMPHT 450 EAQIMNMETR 460 TLAELNTPGE 470 LCIRGYCVMQ 480 GYWGDPQKTD 490 EVIGQDKWYR 500 TGDIAVMDEQ 510 GFCRIVGRAK 520 DMIIRGGENI 530 YPAELEDFFH 540 THPQVQDVQV 550 VGVKDNRMGE 560 EICACIRLKK 570 GEKTTAEEIK 580 AFCKGKISHF 590 KIPRYIVFVT 600 DYPSPSRERS 610 RNSNFESRWN NV

Gene Ontology

Classification	GO ID	Description
Molecular Function	GO:0031956	medium-chain fatty acid-CoA ligase activity
Biological Process	GO:0006629	lipid metabolic process

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.