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Overview

Uniprot IDA0A287ANS5
Protein NameSerine/arginine repetitive matrix protein 1
Gene NameSRRM1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
36 KFAECLEKKVDMSKV

Function

Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates

Protein Sequence

10 MDAGFFRGTS 20 AEQDNRFSNK 30 QKKLLKQLKF 40 AECLEKKVDM 50 SKVNLEVIKP 60 WITKRVTEIL 70 GFEDDVVIEF 80 IFNQLEVKNP 90 DSKMMQINLT 100 GFLNGKNARE 110 FMGELWPLLL 120 SAQENIAGIP 130 SAFLELKKEE 140 IKQRQIEQEK 150 LASMKKQDED 160 KDKRDKEEKE 170 SSREKRERSR 180 SPRRRKSRSP 190 SPRRRSSPVR 200 RERKRSHSRS 210 PRHRTKSRSP 220 SPAPEKKEKT 230 PELPEPSVKV 240 KEPSVQEATS 250 TSDILKVPKP 260 EPVPEPKEPS 270 PEKNSKKEKE 280 KEKTRPRSRS 290 RSKSRSRTRS 300 RSPSHTRPRR 310 RHRSRSRSYS 320 PRRRPSPRRR 330 PSPRRRTPPR 340 RMPPPPRHRR 350 SRSPVRRRRR 360 SSASLSGSSS 370 SSSSSRSRSP 380 PKKAPKRTSS 390 PPRKTRRLSP 400 SASPPRRRHR 410 PSPPATPPPK 420 TRHSPTPQQS 430 NRTRKSRVSV 440 SPGRTSGKVT 450 KHKGTEKRES 460 PSPAPKPRKV 470 ELSESDSGSS 480 SSSEDERPKR 490 SHVKNGEVGR 500 RRRHTPSRSA 510 SPSPRKRQKE 520 TSPRGRRRRS 530 PSPPPTRRRR 540 SPSPAPPPRR 550 RRSPTPPPRR 560 RTPSPPPRRR 570 SPSPRRYSPP 580 IQRRYSPSPP 590 PKRRTASPPP 600 PPKRRASPSP 610 PPKRRVSHSP 620 PPKQRSSPVT 630 KRRSPSLSSK 640 HRKGPSPSRS 650 TREARSPQPN 660 KRHSPSPRPR 670 APQTCSSPPP 680 ARRGASSSPQ 690 RRQSPSPSSR 700 PIRRVSRTPE 710 PKKTKKVASP 720 SPQSVRRVSS 730 SRSVSGSPEP 740 AAKKPPAPPS 750 PVQSQSPSTN 760 WSPAVPVKKA 770 KSPTPSPSPA 780 RNSDPEGGGK 790 KKKKKKDKKH 800 KKDKKHKKHK 810 KHKKEKAVAA 820 AAAAAVTPTA 830 IAAPTTTSAQ 840 EEPEAEPEPK 850 KETESEAEDN 860 LDDLEKHLRE 870 KALRSMRKAQ VSPQS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005681 spliceosomal complex
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.