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Overview

Uniprot ID	A0A287ANT8
Protein Name	Vesicle-fusing ATPase
Gene Name	NSF
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
106	EIDFLQKKSIDSNPY
255	QMGCKHVKGILLYGP
640	KAPPQGRKLLIIGTT
709	KKVWIGIKKLLMLIE
729	DPEYRVRKFLALLRE

Function

Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin

Protein Sequence

10 LLKGRSMQAA 20 RCPTDELSLS 30 NCAVVNEKDF 40 QSGQHVVVRT 50 SPNHRYTFTL 60 RTHPSVVPGS 70 IAFSLPQRKW 80 AGLSIGQEIE 90 VSSYTFDKAK 100 QCIGTMTMEI 110 DFLQKKSIDS 120 NPYDTDKMAA 130 EFIQQFNNQA 140 FSVAQQLVFS 150 FNEKLFGLLV 160 KDIEAMDPSI 170 LKGEPGTGKR 180 QKIEVGLVVG 190 NSQVAFEKAE 200 NSSLNLIGKA 210 KTKENRQSII 220 NPDWNFEKMG 230 IGGLDKEFSD 240 IFRRAFASRV 250 FPPEIVEQMG 260 CKHVKGILLY 270 GPPGCGKTLL 280 ARQIGKMLNA 290 REPKVVNGPE 300 ILNKYVGESE 310 ANIRKLFADA 320 EEEQRRLGAN 330 SGLHIIIFDE 340 IDAICKQRGS 350 MAGSTGVHDT 360 VVNQLLSKID 370 GVEQLNNILV 380 IGMTNRPDLI 390 DEALLRPGRL 400 EVKMEIGLPD 410 EKGRLQILHI 420 HTARMRGHQL 430 LSADVDIKEL 440 AVETKNFSGA 450 ELEGLVRAAQ 460 STAMNRHIKA 470 STKVEVDMEK 480 AESLQVTRGD 490 FLASLENDIK 500 PAFGTNQEDY 510 ASYIMNGIIK 520 WGDPVTRVLE 530 DGELLVQQTK 540 NSDRTPLVSV 550 LLEGPPHSGK 560 TALAARIAEE 570 SNFPFIKICS 580 PDKMIGFSET 590 AKTVDAEKSE 600 CLEYVHIYIE 610 FLNNNNASLP 620 DYVPIGPRFS 630 NLVLQALLVL 640 LKKAPPQGRK 650 LLIIGTTSRK 660 DVLQEMEMLN 670 AFSTTIHVPN 680 IATGEQLLEA 690 LELLGNFKDK 700 ERTTIAQQVK 710 GKKVWIGIKK 720 LLMLIEMSLQ 730 MDPEYRVRKF 740 LALLREEGAS 750 PLDFENELFS NAK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0046872	metal ion binding
Biological Process	GO:0015031	protein transport
Biological Process	GO:0035494	SNARE complex disassembly

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.