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Overview

Uniprot IDA0A287AP37
Protein NameADP-ribosylation factor-related protein 1
Gene NameARFRP1
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
112 EERLCESKCAFEKMV

Function

Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver

Protein Sequence

10 MYTLLSGLYK 20 YMFQKDEYCI 30 LILGLDNAGK 40 TTFLEQSKTR 50 FNKNYKGMSL 60 SKITTTVGLN 70 IGTVDVGKAR 80 LMFWDLGGQE 90 ELQSLWDKYY 100 AECHGVIYVI 110 DSTDEERLCE 120 SKCAFEKMVT 130 SEALDGVPIL 140 VLANKQDIET 150 CLSIPDIKTA 160 FSDCISKIGR 170 RDCLTQACSA 180 LTGKGVREGI 190 EWMVKCVVRN 200 VHRPPRQRDI T

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0016020 membrane
Cellular Component GO:0005802 trans-Golgi network
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0046872 metal ion binding
Biological Process GO:0043001 Golgi to plasma membrane protein transport
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0034067 protein localization to Golgi apparatus
Biological Process GO:0042147 retrograde transport, endosome to Golgi

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.