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Overview

Uniprot ID	A0A287AP46
Protein Name	Zinc finger CCCH domain-containing protein 14
Gene Name	ZC3H14
Organism	Sus scrofa

Kla Sites from experimental identification

Position	Flanking peptide
126	VSSTRPEKRDSRVST
307	SSVVKVKKFNHDGEE
352	PPSKQANKNLILKAI
665	RYFPACKKMECPFYH
703	VPPRHALKWIRPQTS

Function

RNA-binding protein involved in the biogenesis of circular RNAs (circRNAs), which are produced by back-splicing circularization of pre-mRNAs. Acts by binding to both exon-intron boundary and 3'-UTR of pre-mRNAs to promote circRNA biogenesis through dimerization and the association with the spliceosome. Required for spermatogenesis via involvement in circRNA biogenesis. Regulates the pre-mRNA processing of ATP5MC1; preventing its degradation. Also binds the poly(A) tail of mRNAs; controlling poly(A) length in neuronal cells

Protein Sequence

10 MEIGTEISRK 20 IRSAIKGKLQ 30 ELGAYVDEEL 40 PDYIMVMVAN 50 KKSQDQMTED 60 LSLFLGNNTI 70 RFTVWLHGVL 80 DKLRSVTTDP 90 SSFKSSDTNI 100 FDSNVPSNKS 110 SFSRGDERRH 120 EAAVPPLAVS 130 STRPEKRDSR 140 VSTSSQEQKA 150 TNVRQTYDDG 160 AATRLMSTVK 170 PLREPAPSED 180 VIDIKPEPDD 190 LIDEDLNFVQ 200 ENPLSQKKPT 210 VTLTYGSSRP 220 SIEIYRPPAS 230 RNADSGAHLN 240 RLQFQQQQNS 250 IHAAKQVDIQ 260 SSRVYETGRL 270 CEPEVLNSLE 280 ETYSPFFRNN 290 SEKMSIEEEN 300 FRKRKLPVVS 310 SVVKVKKFNH 320 DGEEEEEEDD 330 CGSRTGSISS 340 SVSVPAKPER 350 RPSLPPSKQA 360 NKNLILKAIS 370 EAQESVTKTT 380 NYSTVSQKQT 390 LPVAPRTRTS 400 QEELLAEMVQ 410 GQSKAPRISS 420 PIKEEETKGD 430 NIDKSQDYYD 440 MESMVHADTR 450 SFILKKPKLS 460 EEIVVAPNQE 470 SGMKTADTLR 480 VLSGHLMQTR 490 DLVQPDKPAS 500 PKFIVTLDGV 510 PSPPGYMSDQ 520 EEDMCFEGMR 530 PAHHTAASHE 540 GLAGLLHPQQ 550 LHLLSRQLED 560 PDGSFSNAEM 570 SELSVAQKPE 580 KLLERCKYWP 590 ACKNGDECAY 600 HHPISPCKAF 610 PNCKFAEKCL 620 FVHPNCKYDA 630 KCTKPDCPFT 640 HMSRRIPVLP 650 PKPAVTTPAP 660 PSSSQLCRYF 670 PACKKMECPF 680 YHPKHCRFNT 690 QCTRPDCTFY 700 HPTITVPPRH 710 ALKWIRPQTS E

Gene Ontology

Classification	GO ID	Description
Biological Process	GO:0043488	regulation of mRNA stability
Cellular Component	GO:0016607	nuclear speck
Molecular Function	GO:0008143	poly(A) binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0007283	spermatogenesis

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.