Search Results
Overview
| Uniprot ID | A0A287AP77 |
|---|---|
| Protein Name | Multivesicular body subunit 12A |
| Gene Name | MVB12A |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | VRLSGKTKTVPGYLR |
Function
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor
Protein Sequence
10
MDPGPGTDAA
20
PLAGLAWSSA
30
SAPPPRGFSA
40
ISCTVEGAPA
50
SFGKTFAQKS
60
GYFLCLNPLG
70
SLENPQENVV
80
VDIQILVDKS
90
PLPPGFSPVC
100
DPVDSKSVSK
110
KKRMCVKLVP
120
LGVADTAVFD
130
VRLSGKTKTV
140
PGYLRVGDMG
150
GFAIWCKKAK
160
APRPVPKPRA
170
LSRDMRDLSL
180
DQPSQPSKGG
190
FPERTLSRLG
200
SASTLRRNDS
210
IYEASNLYGI
220
SAMDGVPFTL
230
HPRFEGKSCG
240
PLAFSAFADL
250
TIKSLADIEE
260
EYNYGFVVEK
270
TAAARLPPSV
S
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0000813 | ESCRT I complex |
| Cellular Component | GO:0031902 | late endosome membrane |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0043130 | ubiquitin binding |
| Biological Process | GO:0032510 | endosome to lysosome transport via multivesicular body sorting pathway |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0032801 | receptor catabolic process |
| Biological Process | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0046755 | viral budding |
| Biological Process | GO:0019075 | virus maturation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.