Search Results

Overview

Uniprot IDA0A287APA5
Protein NameProtein 4.1
Gene NameEPB41L3
OrganismSus scrofa

Kla Sites from experimental identification

Position Flanking peptide
392 RAAKRLWKVCVEHHT
412 LPEAPPKKFLTLGSK

Function

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase

Protein Sequence

10 MGPLLSLFAE 20 QSTMTTESGS 30 DSESKPEQEA 40 EPQEAAGPQG 50 HAGGQPGPEP 60 GAEEQPQAPE 70 QFEEAAAHST 80 PVRKEVTDKE 90 QEFAAAAAKQ 100 LEYQQFEDDK 110 LSQKSSSSKL 120 SRSPLKIVKK 130 PKSMQCKVIL 140 LDGSEYTCDV 150 EKRSRGQVLF 160 DKVCEHLNLL 170 EKDYFGLTYR 180 DAENQKNWLD 190 PAKEIKKQIR 200 SGAWHFSFNV 210 KFYPPDPAQL 220 SEDITRYYLC 230 LQLRDDIVSG 240 RLPCSFVTLA 250 LLGSYTVQSE 260 LGDYDPDECG 270 SDYVSEFRFA 280 PNHTKELEDK 290 VIELHKSHRG 300 MTPAEAEMHF 310 LENAKKLSMY 320 GVDLHHAKDS 330 EGVDIMLGVC 340 ASGLLIYRDR 350 LRINRFAWPK 360 VLKISYKRNN 370 FYIKIRPGEF 380 EQFESTIGFK 390 LPNHRAAKRL 400 WKVCVEHHTF 410 FRLLLPEAPP 420 KKFLTLGSKF 430 RYSGRTQAQT 440 RRASALIDRP 450 APYFERSSSK 460 RYTMSRSLDG 470 EVGTGQYATT 480 KGISQTNLIT 490 TVTPEKKAEE 500 ERDEEEERRK 510 KAEEATPVAT 520 VRHEGKTDSE 530 RTDTAADGET 540 TATEEMLHGD 550 ELDKTQDDLM 560 KHQTNISELK 570 RTFLETSTDT 580 AVTNEWEKRL 590 STSPVRLAAR 600 PEEAPMIEPL 610 VPEETKEERE 620 ISEKVIYLQQ 630 GSSPVFESQP 640 SVIKNIQEGD 650 SAGSVFTSHQ 660 IIFQKTVPST 670 LEGTEDWVIV 680 DKIPTEVVDG 690 DSKKIVTYKV 700 VTLSSRTGDI 710 PADLLGSSAV 720 EVQSFEDLAR 730 EMHLKEDSRQ 740 KIYTLGRSYD 750 TVSGKIVTMT 760 GKAKEGEKVV 770 PPSPLELGLA 780 ESMKTPLVLA 790 ELGVLGASAE 800 DRARRGPEVH 810 TPKRRLSESL 820 TPIKEAESRR 830 PSPEDAEPWR 840 EAGPESARLR 850 AEPEAEALKV 860 GPFGPRRKSL 870 SEWRYSQEPA 880 VTVATARYVT 890 EAAASQVVTK 900 QSSGEKLMDG 910 SEIFSLLESA 920 RKPTEFIGGV 930 TSTSQSWVQK 940 TETKTESSET 950 ETETTQRPQP 960 LSTETVVQET 970 VLVEERHVMS 980 VHASGDASST 990 AGDGVDAAAQ 1000 AASAEASGVK 1010 GKEGSALTEG 1020 AKEDKGEVAD 1030 RAVLEQEVMA 1040 TASQEPEEER 1050 LSAAIHVSET 1060 LEQKPHFESS 1070 TVKTETISFG 1080 SVSPGGIKLE 1090 ISTKEVPVVH 1100 TETKTITYES 1110 SQVDLGADLE 1120 PGVLMSAQTI 1130 TSETTSTTTT 1140 THITRTVKGG 1150 ISETRIEKRI 1160 VITGDADIDH 1170 DQALAQAIKE 1180 AKEQHPDMSV 1190 TKVVVHKETE ITPEDGED

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005938 cell cortex
Cellular Component GO:0005911 cell-cell junction
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0003779 actin binding
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0031032 actomyosin structure organization
Biological Process GO:0030866 cortical actin cytoskeleton organization

Reference

[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.